NP antibody

Principal name

NP antibody

Alternative names for NP antibody

PNP, PNP1, Inosine Phosphorylase, Purine Nucleoside Phosphorylase

SwissProt ID

P00491 (Human), P23492 (Mouse), P55859 (Bovin), P85973 (Rat)

Gene ID

4860 (PNP), 18950 (Pnp)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R)

Background of NP antibody

Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Dautant A., et al. (2010) J Biol Chem. 285(38):29502-10.
Balakrishnan K., et al. (2010) Blood. 116(6):886-92.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NP (142-153) antibody

AP32724PU-N PNP Antibody staining of Human Liver lysate  at 0.1µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NP antibody

  Rabbit anti-PNP Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PNP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

NP antibody

NP Rabbit IgG Azide Free Bov Dot, E, ICC/IF, ID, IP, R, WB
10 mg / €240.00
  Acris Antibodies GmbH

NP antibody

NP Rabbit IgG Biotin Bov Dot, E, ICC/IF, ID, IP, R, WB
1 ml / €350.00
  Acris Antibodies GmbH

NP antibody

NP Rabbit IgG Aff - Purified Bov Dot, E, ICC/IF, ID, IP, R, WB
1 mg / €440.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PNP - human gene knockout kit via CRISPR

PNP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PNP - human gene knockout kit via CRISPR

PNP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PNP - human gene knockout kit via CRISPR

PNP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PNP - human gene knockout kit via CRISPR

PNP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NP

  Recombinant protein of human nucleoside phosphorylase (NP)  
NP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

NP (1-289, His-tag)

NP Human Purified > 90 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

NP (1-289, His-tag)

NP Human Purified > 90 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PNP (mGFP-tagged) - Human purine nucleoside phosphorylase (PNP), 200 uL, >10^7 TU/mL

Lenti ORF particles, PNP (mGFP-tagged) - Human purine nucleoside phosphorylase (PNP), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, PNP (Myc-DDK tagged) - Human purine nucleoside phosphorylase (PNP) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PNP (Myc-DDK tagged) - Human purine nucleoside phosphorylase (PNP) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Pnp (GFP-tagged) - Mouse purine-nucleoside phosphorylase (Pnp), 200 uL, >10^7 TU/mL

Lenti ORF particles, Pnp (GFP-tagged) - Mouse purine-nucleoside phosphorylase (Pnp), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

15 Item(s)

per page
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