NPC1 antibody

Principal name

NPC1 antibody

Alternative names for NPC1 antibody

Niemann-Pick C1 protein

SwissProt ID

O15118 (Human), O35604 (Mouse), P56941 (Pig)

Gene ID

4864 (NPC1)

Available reactivities

Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunoelectron Microscopy (EM), Flow Cytometry (F)

Background of NPC1 antibody

Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-termil domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NPC1 antibody

Western Blot: Niemann-Pick C1 Antibody [TA336646] - Detection of human NPC1 in 20 ug of human fibroblast cell lysate. Rabbit Purified Hu, Ms, Por, Rt C, EM, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NPC1 antibody

AP60000PU-N (0.5µg/ml) staining of HEK293 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

NPC1 antibody

Western blot analysis of NPC1 in human kidney tissue lysate with NPC1 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NPC1 Control Peptide

NPC1
50 µg / €160.00
  Acris Antibodies GmbH

NPC1 antibody

Detection limit for recombinant GST tagged NPC1 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 4H2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

NPC1 antibody

Western blot analysis of NPC1 in 20 µg of human fibroblast cell lysate with NPC1 polyclonal antibody ( Cat# PAB12093 ). Rabbit Hst, Hu, Ms C, EM, ICC/IF, IP, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

NPC1 antibody

NPC1 Rabbit Biotin Hst, Hu, Ms ICC/IF, IP, P, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

NPC1 antibody

NPC1 Rabbit DyLight488 Hu, Ms ICC/IF, IP, P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

NPC1 antibody

NPC1 Rabbit HRP Hst, Hu, Ms ICC/IF, IP, P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

NPC1 antibody

NPC1 Rabbit Aff - Purified Hst, Hu, Mky, Ms ICC/IF, IP, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NPC1

NPC1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

NPC1

NPC1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

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