NPR1 / ANPRA antibody

Principal name

NPR1 / ANPRA antibody

Alternative names for NPR1 / ANPRA antibody

ANP receptor A, ANP-A, NPR-A, Guanylate cyclase, GC-A, Atrial natriuretic peptide A-type receptor

SwissProt ID

P16066 (Human), P18293 (Mouse), P18910 (Rat)

Gene ID

4881 (NPR1), 18160 (Npr1), 24603

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of NPR1 / ANPRA antibody

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kise-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for triuretic peptides; they are also referred to as atrial triuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain triuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009].

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NPR1 / ANPRA antibody

Predicted cell location: Nucleus. Positive control: Human liver cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using NPR1 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NPR1 / ANPRA antibody

Predicted cell location: Cytoplasm. Positive control: Human brain and gastric cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using NPR1 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NPR1 / ANPRA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NPR1 (RC209267, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NPR1. Mouse IgG1 OTI7H7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR1 / ANPRA (294-308) antibody

Immunocytochemistry of NPR-A staining in cultured Rat inner medullary collecting duct (IMCD) cells. The cells were grown on glass slides and fixed in 4% paraformaldehyde. The cells were incubated with AP02128SU for 90 min, followed by an appropriate secondary antibody coupled to Alexa488. Scale bar = 20 µm. 
 Klokkers J et al. (2009)Am. J. Physiol. Renal. Physiol. 297(3): F693-703. Rabbit Serum Hu ICC/IF, P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

NPR1 / ANPRA (294-308) antibody

Immunocytochemistry of NPR-A staining in cultured Rat inner medullary collecting duct (IMCD) cells. The cells were grown on glass slides and fixed in 4% paraformaldehyde. The cells were incubated with AP02128SU for 90 min, followed by an appropriate secondary antibody coupled to Alexa488. Scale bar = 20 µm. 
 Klokkers J et al. (2009)Am. J. Physiol. Renal. Physiol. 297(3): F693-703. Rabbit Serum Hu ICC/IF, P, WB
20 µl / €170.00
  Acris Antibodies GmbH

NPR1 / ANPRA (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms, Rt ICC/IF
0.4 ml / €370.00
  Acris Antibodies GmbH

NPR1 / ANPRA antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with NPR1 polyclonal antibody ( Cat # PAB3327 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu, Ms, Rt E, ICC/IF, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NPR1 / ANPRA

NPR1 / ANPRA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

NPR1 / ANPRA

NPR1 / ANPRA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

NPR1 / ANPRA

NPR1 / ANPRA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

NPR1 overexpression lysate

NPR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NPR1 (mGFP-tagged) - Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1), 200 uL, >10^7 TU/mL

Lenti ORF particles, NPR1 (mGFP-tagged) - Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPR1 (Myc-DDK tagged) - Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, NPR1 (Myc-DDK tagged) - Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1) , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

13 Item(s)

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