NPR1 / ANPRA antibody

Principal name

NPR1 / ANPRA antibody

Alternative names for NPR1 / ANPRA antibody

ANP receptor A, ANP-A, NPR-A, Guanylate cyclase, GC-A, Atrial natriuretic peptide A-type receptor

SwissProt ID

P16066 (Human), P18293 (Mouse), P18910 (Rat)

Gene ID

4881 (NPR1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of NPR1 / ANPRA antibody

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kise-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for triuretic peptides; they are also referred to as atrial triuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain triuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009].

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NPR1 / ANPRA antibody

Predicted cell location: Nucleus. Positive control: Human liver cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using NPR1 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NPR1 / ANPRA antibody

Predicted cell location: Cytoplasm. Positive control: Human brain and gastric cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using NPR1 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

NPR1 / ANPRA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NPR1 (RC209267, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NPR1. Mouse IgG1 OTI7H7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR1 / ANPRA (294-308) antibody

Immunocytochemistry of NPR-A staining in cultured Rat inner medullary collecting duct (IMCD) cells. The cells were grown on glass slides and fixed in 4% paraformaldehyde. The cells were incubated with AP02128SU for 90 min, followed by an appropriate secondary antibody coupled to Alexa488. Scale bar = 20 µm. 
 Klokkers J et al. (2009)Am. J. Physiol. Renal. Physiol. 297(3): F693-703. Rabbit Serum Hu ICC/IF, P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

NPR1 / ANPRA (294-308) antibody

Immunocytochemistry of NPR-A staining in cultured Rat inner medullary collecting duct (IMCD) cells. The cells were grown on glass slides and fixed in 4% paraformaldehyde. The cells were incubated with AP02128SU for 90 min, followed by an appropriate secondary antibody coupled to Alexa488. Scale bar = 20 µm. 
 Klokkers J et al. (2009)Am. J. Physiol. Renal. Physiol. 297(3): F693-703. Rabbit Serum Hu ICC/IF, P, WB
20 µl / €170.00
  Acris Antibodies GmbH

NPR1 / ANPRA (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms, Rt ICC/IF
0.4 ml / €370.00
  Acris Antibodies GmbH

NPR1 / ANPRA antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with NPR1 polyclonal antibody ( Cat # PAB3327 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu, Ms, Rt E, ICC/IF, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

NPR1 / ANPRA antibody

Immunofluorescence: Natriuretic Peptide Receptor A Antibody [NBP1-31333] - Immunofluorescence analysis of HeLa, using NBP1-31333 at 1:200 dilution. Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

NPR1 / ANPRA antibody

Western Blot: Natriuretic Peptide Receptor A Antibody [NBP1-32889] - Westsern blot analysis of Natriuretic Peptide Receptor A Antibody on HeLa whole cell lysate using NBP1-32889. Rabbit IgG Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NPR1 / ANPRA

NPR1 / ANPRA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

NPR1 / ANPRA

NPR1 / ANPRA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

NPR1 / ANPRA

NPR1 / ANPRA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

NPR1 overexpression lysate

NPR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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