NPR3 / ANPRC antibody

Principal name

NPR3 / ANPRC antibody

Alternative names for NPR3 / ANPRC antibody

Atrial natriuretic peptide C-type receptor, ANP clearance receptor, ANP-C, NPR-C

SwissProt ID

P10730 (Bovin), P17342 (Human), P41740 (Rat), P70180 (Mouse)

Gene ID

4883 (NPR3)

Available reactivities

Hu (Human), Rt (Rat), Chk (Chicken), Mky (Monkey), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Xen (Xenopus)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F)

Background of NPR3 / ANPRC antibody

The family of natriuretic peptides comprised of several 22-53 amino acid peptides with vasoadilator and diuretic properties and plays a pivotal role in cardiovascular homeostasis. So far we have five natriuretic peptides known ANP, urodilin, BNP, CNP and DNP. The pro-hormones for ANP, BNP and CNP are encoded by different genes. The arterial natriuretic peptide (ANP) and the brain natriuretic peptide (BNP) are secreted as pro-hormones (Pro-ANP and Pro-BNP) and their levels are significantly increases in non survival cardiac dysfunction patients (1). They are also useful as a laboratory markers for myocardial dysfunction and various other clinical conditions such as pulmonary thrombo embolism, transient tachypnea, sepsis and stroke. The levels of these peptides may also differentiate between survival and non-survival acute sepsis. The Pro ANP is stored in the cells and is released upon stretch from artria into circulation. The rate limiting protease, corin, a trans-membrane serine protease converts Pro-ANP is to ANP for immediate release in to circulation. The release of ANP causes an increased in cGMP in the cells by acting on 3 types of ANP receptors (NPRA, NPRB and NPRC). ANP regulates a variety of physiological parameters by interacting with its receptors present on the plasma membrane. These are of three subtypes NPR-A, NPR-B, and NPR-C. NPR-A and NPR-B are guanylyl cyclase receptors, whereas NPR-C is non-guanylyl cyclase receptor and is coupled to adenylyl cyclase inhibition or phospholipase C activation through inhibitory guanine nucleotide regulatory protein (Gi).
Unlike other G-protein-coupled receptors, ANP type C receptors have a single transmembrane domain with structural specificity that lies near the short C-terminal end which inhibit adenylyl cyclase. NPRC also stimulates phosphatidyl inositol (PI) turnover in vascular smooth muscle cells (VSMC) which is attenuated by cAMP analogues. NPRC receptor is also a candidate susceptibility gene for essential hypertension or obese hypertension as it plays a key role in the regulation of plasma levels and biological effects of natriuretic peptides. The C-type NPR (NPR-C) is responsible for clearance of NP hormones from the circulation, and displays cross-reactivity for all NP hormones (ANP, BNP, and CNP). The NPRC receptor is expressed in dorsal root sensory and cranial ganglion and in Schwann cells. NPRC also regulates salt excretion, vascular tone, and fibroblast proliferation and activation (1).
The NPRC is a 443 aa, 55 kDa protein with a single transmembrane domain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501021, Dilution 1:50) Mouse IgG2b OTI4C3 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501044, Dilution 1:50) Mouse IgG2b OTI4H1 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501080, Dilution 1:50) Mouse IgG2b OTI11H6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-NPR3mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500956, Dilution 1:50) Mouse IgG2b OTI2G2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. TA308692 diluted at 1:10000 Rabbit IgG Aff - Purified Chk, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500955, Dilution 1:50) Mouse IgG2b OTI2C2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501046, Dilution 1:50) Mouse IgG3 OTI4A1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501076, Dilution 1:50) Mouse IgG2b OTI11A6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501077, Dilution 1:50) Mouse IgG2b OTI11B6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded prostate tissue within the normal limits using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501078, Dilution 1:50) Mouse IgG2b OTI11H5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-NPR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501079, Dilution 1:50) Mouse IgG2b OTI11B5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC (520-533) antibody

TA309540 (1µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NPR3 / ANPRC (N-term) antibody

Western blot analysis of ANPC-S82 (Cat. #TA325025) in NCI-H460,HL-60 cell line lysates (35ug/lane). ANPC (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

NPR3 / ANPRC antibody

Anti-NPR3 mouse monoclonal antibody (TA501045) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY NPR3(RC219453 ). Mouse IgG2a OTI2B12 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NPR3 / ANPRC antibody

ELISA: Natriuretic Peptide Receptor C Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

NPR3 / ANPRC (199-213) antibody

NPR3 / ANPRC Rabbit Serum Hu, Rt C, ICC/IF, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

NPR3 / ANPRC (199-213) antibody

NPR3 / ANPRC Rabbit Serum Hu, Rt C, ICC/IF, WB
20 µl / €170.00
  Acris Antibodies GmbH

NPR3 / ANPRC Control Peptide

NPR3 / ANPRC
0.25 mg / €250.00
  Acris Antibodies GmbH

NPR3 / ANPRC (496-515) antibody

NPR3 / ANPRC Rabbit Aff - Purified Hu, Mky, Ms, Rt C, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

NPR3 / ANPRC antibody

NPR3 polyclonal antibody (A01), Lot # UHB5051129QCS1 Western Blot analysis of NPR3 expression in HeLa ( Cat # L013V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Items 1 to 20 of 26 total

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