NPY receptor 4 / NPY4R antibody

Principal name

NPY receptor 4 / NPY4R antibody

Alternative names for NPY receptor 4 / NPY4R antibody

NPY4-R, PPYR1, Pancreatic polypeptide receptor 1, Neuropeptide Y receptor 4

SwissProt ID

P50391 (Human), Q61041 (Mouse), Q63447 (Rat)

Gene ID

5540 (PPYR1), 4852 (NPY), 29471 (Ppyr1)

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Hu (Human), Mky (Monkey), Por (Porcine), Rb (Rabbit), Bear, Gorilla, Rt (Rat)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of NPY receptor 4 / NPY4R antibody

Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems. It belongs to the NPY family, along with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in the regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction. NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R). Four of these (Y1, Y2, Y4, and Y5) are expressed in humans. The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus. Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.Based on their high frequency and density in steroid hormone-producing tumors, the NPYRs might be of potential use in tumor magement. NPY4R preferentially binds PP, while NPY1R, NPY2R, and NPY5R bind both NPY and PP. NPY1R, NPY2R, and NPY5R share a low degree of identity (27–31% overall). NPY4R is more similar to NPY1R, displaying an overall identity of 43–53%. Human NPY4R (also med pancreatic polypeptide receptor 1) mR is highly expressed in the small and large intestines and the prostate. Tissue distribution studies in human and mouse suggest potential roles for NPY4R in the gastrointestil tract, heart, and prostate, as well as in neural and endocrine sigling. Only low levels of NPY4R expression in various areas of brain were displayed.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NPY receptor 4 / NPY4R (C-term) antibody

Anti-PPYR1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Eq, Hu, Por, Rb P
50 µg / €345.00
  OriGene Technologies, Inc.

NPY receptor 4 / NPY4R (2nd extracell. dom.) antibody

Anti-PPYR1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Eq, Hu, Mky, Por, Rb P
50 µg / €345.00
  OriGene Technologies, Inc.

NPY receptor 4 / NPY4R antibody

Anti-PPYR1 antibody IHC of human brain, substantia nigra. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 16 ug/ml. Rabbit IgG Purified Gorilla, Hu, Mky
50 µg / €345.00
  OriGene Technologies, Inc.

NPY receptor 4 / NPY4R antibody

Western blot analysis of rat brain membrane (lanes 1 and 4), cortex (lanes 2 and 5), and hippocampus (lanes 3 and 6) lysates: 1, 2, 3. Anti-Neuropeptide Y4 Receptor antibody , (1:200). 4, 5, 6. Anti-Neuropeptide Y4 Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NPY receptor 4 / NPY4R antibody

WB Suggested Anti-PPYR1 Antibody; Titration: 1.0 ug/ml; Positive Control: HepG2 Whole Cell Rabbit IgG Purified Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NPY receptor 4 / NPY4R antibody

Western Blot analysis of PPYR1 expression in transfected 293T cell line (H00005540-T01) by PPYR1 MaxPab polyclonal antibody.

Lane 1: PPYR1 transfected lysate(42.20 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

NPY receptor 4 / NPY4R antibody

Immunohistochemistry-Paraffin: NPY4R Antibody [NBP1-82534] Immunohistochemical staining of human breast shows strong positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

NPY receptor 4 / NPY4R antibody

Small Intestine, Muscularis Propia Rabbit Aff - Purified Hu P
50 µl / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NPY receptor 4 / NPY4R

NPY receptor 4 / NPY4R Human
2 µg / €450.00
  Abnova Taiwan Corp.

NPY receptor 4 / NPY4R

NPY receptor 4 / NPY4R Human
2 µg / €450.00
  Abnova Taiwan Corp.

NPY receptor 4 / NPY4R

NPY receptor 4 / NPY4R Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
10 µg / €380.00
  Abnova Taiwan Corp.

NPY receptor 4 / NPY4R

NPY receptor 4 / NPY4R Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

NPY4R overexpression lysate

NPY4R overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

13 Item(s)

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