NPY Receptor 5 / NPY5R antibody

Principal name

NPY Receptor 5 / NPY5R antibody

Alternative names for NPY Receptor 5 / NPY5R antibody

NPY5-R, NPY-Y5 receptor, NPYY5, NPYR5, Neuropeptide Y receptor 5

SwissProt ID

O62729 (Canfa), O70342 (Mouse), O97969 (Pig), Q15761 (Human), Q63634 (Rat)

Gene ID

4889 (NPY5R), 25340 (Npy5r), 18168

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Hst (Hamster), Eq (Equine), Por (Porcine)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of NPY Receptor 5 / NPY5R antibody

Neuropeptide Y Receptor Y5 (NPY5R) is a G-Protein Coupled Receptor of the Neuropeptide Y (NPY) receptor family that includes NPY1R and NPY2R; it is located at human chromosome 4q31-32(1). It is activated by the binding of NPY, a neurotransmitter in the central and peripheral nervous system that is though to have a major role in the physiological control of energy homeostasis (2). NPY’s role in energy homeostasis is mediated primarily via NPY5R. NPY5R is a mediator of NPY-induced feeding, fat thermogenesis and energy expenditure (3). It is involved in the regulation and development of diet-induced obesity. In mice, Y5 antagonist produced a fat-selective loss of body weight and ameliorated obesity-associated insulin resistance in diet-induced obese mice (4). Therefore, NPY5R is a potential target in the development of novel treatment of obesity and related feeding disorders.
NPY5R also plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 synapse in the mouse (5). It regulates hippocampal seizures. In mice, following seizure activity NPY levels are up-regulated in the brain which then up-regulates NPY5R expression. Activation of NPY5R has been shown to reduce generalized seizures (6). It is strongly expressed in cortex, putamen, claudate nucleus, CA3 subfield of the ventral hippocampus, amygdala, small intestine and colon. NPY5R is approximately a 56kDa protein (466 amino acids).

General readings

1. Sheriff S, Ali M, Yahya A, Haider KH, Balasubramaniam A, Amlal H. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
Mol Cancer Res. 2010 Apr;8(4):604-14.
PMID: 20332211

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NPY Receptor 5 / NPY5R antibody

  Rabbit Polyclonal Anti-NPY5R Antibody (Cytoplasmic Domain)  
Anti-NPY5R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Hst, Hu, Ms, Rt
50 µg / €400.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

  Rabbit Polyclonal Anti-NPY5R Antibody (Cytoplasmic Domain)  
Anti-NPY5R antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Eq, Hu, Por
50 µg / €400.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

  Goat Polyclonal Antibody against NPY5R  
TA303031 (0.3µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

  Rabbit polyclonal Anti-Neuropeptide Y5 Receptor  
Western blot analysis of rat brain membrane: 1. Anti-Neuropeptide Y5 Receptor antibody , (1:200). 2. Anti-Neuropeptide Y5 Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry (IHC) analyzes of NPY5-R antibody (Cat.-No.: AP01324PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R Control Peptide

NPY Receptor 5 / NPY5R
0.25 mg / €250.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R (C-term) antibody

Western blot of NPY5R (1:500) with Western blot positive control. Rabbit Aff - Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R antibody

Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using NPY5R Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using NPY5R Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

NPY5R - human gene knockout kit via CRISPR

NPY5R - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NPY5R - human gene knockout kit via CRISPR

NPY5R - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NPY5R - human gene knockout kit via CRISPR

NPY5R - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NPY5R - human gene knockout kit via CRISPR

NPY5R - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Npy5r - mouse gene knockout kit via CRISPR

Npy5r - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Npy5r - mouse gene knockout kit via CRISPR

Npy5r - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Npy5r - mouse gene knockout kit via CRISPR

Npy5r - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Npy5r - mouse gene knockout kit via CRISPR

Npy5r - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NPY5R (mGFP-tagged)-Human neuropeptide Y receptor Y5 (NPY5R), 200 uL, >10^7 TU/mL

Lenti ORF particles, NPY5R (mGFP-tagged)-Human neuropeptide Y receptor Y5 (NPY5R), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, NPY5R (Myc-DDK-tagged)-Human neuropeptide Y receptor Y5 (NPY5R), 200 uL, >10^7 TU/mL

Lenti ORF particles, NPY5R (Myc-DDK-tagged)-Human neuropeptide Y receptor Y5 (NPY5R), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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