NPY Receptor 5 / NPY5R antibody

Principal name

NPY Receptor 5 / NPY5R antibody

Alternative names for NPY Receptor 5 / NPY5R antibody

NPY5-R, NPY-Y5 receptor, NPYY5, NPYR5, Neuropeptide Y receptor 5

SwissProt ID

O62729 (Canfa), O70342 (Mouse), O97969 (Pig), Q15761 (Human), Q63634 (Rat)

Gene ID

4889 (NPY5R), 25340 (Npy5r)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Hst (Hamster), Eq (Equine), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of NPY Receptor 5 / NPY5R antibody

Neuropeptide Y Receptor Y5 (NPY5R) is a G-Protein Coupled Receptor of the Neuropeptide Y (NPY) receptor family that includes NPY1R and NPY2R; it is located at human chromosome 4q31-32(1). It is activated by the binding of NPY, a neurotransmitter in the central and peripheral nervous system that is though to have a major role in the physiological control of energy homeostasis (2). NPY’s role in energy homeostasis is mediated primarily via NPY5R. NPY5R is a mediator of NPY-induced feeding, fat thermogenesis and energy expenditure (3). It is involved in the regulation and development of diet-induced obesity. In mice, Y5 antagonist produced a fat-selective loss of body weight and ameliorated obesity-associated insulin resistance in diet-induced obese mice (4). Therefore, NPY5R is a potential target in the development of novel treatment of obesity and related feeding disorders.
NPY5R also plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 synapse in the mouse (5). It regulates hippocampal seizures. In mice, following seizure activity NPY levels are up-regulated in the brain which then up-regulates NPY5R expression. Activation of NPY5R has been shown to reduce generalized seizures (6). It is strongly expressed in cortex, putamen, claudate nucleus, CA3 subfield of the ventral hippocampus, amygdala, small intestine and colon. NPY5R is approximately a 56kDa protein (466 amino acids).

General readings

1. Sheriff S, Ali M, Yahya A, Haider KH, Balasubramaniam A, Amlal H. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
Mol Cancer Res. 2010 Apr;8(4):604-14.
PMID: 20332211

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NPY Receptor 5 / NPY5R antibody

Anti-NPY5R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Hst, Hu, Ms, Rt
50 µg / €379.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

Anti-NPY5R antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Eq, Hu, Por
50 µg / €379.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

TA303031 (0.3µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

Western blot analysis of rat brain membrane: 1. Anti-Neuropeptide Y5 Receptor antibody , (1:200). 2. Anti-Neuropeptide Y5 Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry (IHC) analyzes of NPY5-R antibody (Cat.-No.: AP01324PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R Control Peptide

NPY Receptor 5 / NPY5R
0.25 mg / €250.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R (C-term) antibody

Western blot of NPY5R (1:500) with Western blot positive control. Rabbit Aff - Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R antibody

Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

NPY Receptor 5 / NPY5R antibody

Western Blot analysis of NPY5R expression in transfected 293T cell line (H00004889-T01) by NPY5R MaxPab polyclonal antibody.

Lane 1: NPY5R transfected lysate(48.95 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

NPY Receptor 5 / NPY5R antibody

NPY5R polyclonal antibody ( Cat # PAB6799 ) ( 0.3 µg/ml ) staining of human brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using NPY5R Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using NPY5R Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry-Paraffin: NPY5R Antibody [NB100-1538] - (3.8ug/ml) staining of paraffin embedded Human Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

NPY Receptor 5 / NPY5R antibody

Immunohistochemistry: NPY5-R Antibody [NBP1-00957] - Immunohistochemistry (IHC) analyzes of NPY5-R (M264) antibody in paraffin-embedded human breast carcinoma tissue Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NPY Receptor 5 / NPY5R

NPY Receptor 5 / NPY5R Human
10 µg / €540.00
  Abnova Taiwan Corp.

NPY Receptor 5 / NPY5R

NPY Receptor 5 / NPY5R Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

NPY Receptor 5 / NPY5R

NPY Receptor 5 / NPY5R Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

NPY5R 293T Cell Transient Overexpression Lysate(Denatured)

NPY5R 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

18 Item(s)

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