NR0B2 antibody

Principal name

NR0B2 antibody

Alternative names for NR0B2 antibody

SHP, Nuclear receptor subfamily 0 group B member 2,Orphan nuclear receptor SHP, Small heterodimer partner

SwissProt ID

P97947 (Rat), Q15466 (Human), Q62227 (Mouse)

Gene ID

8431 (NR0B2), 117274 (Nr0b2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ze (Zebrafish), Eq (Equine), Por (Porcine), Rb (Rabbit), Rt (Rat), GP (Guinea Pig), Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of NR0B2 antibody

NR0B2 is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. It is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Park,W.I., (2008) Biochem. Biophys. Res. Commun. 369 (2), 437-443

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NR0B2 antibody

  Rabbit anti-NR0B2 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using NR0B2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR0B2 antibody

  NR0B2 mouse monoclonal antibody, clone OTI5F10 (formerly 5F10)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NR0B2 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806319) Dilution: 1:150 Mouse IgG2a OTI5F10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR0B2 antibody

  NR0B2 mouse monoclonal antibody, clone OTI7B5 (formerly 7B5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NR0B2 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806321) Dilution: 1:150 Mouse IgG2a OTI7B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR0B2 antibody

  NR0B2 mouse monoclonal antibody, clone OTI8E5 (formerly 8E5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NR0B2 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806345) Dilution: 1:150 Mouse IgG1 OTI8E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR0B2 antibody

  Rabbit Polyclonal antibody to NR0B2 (nuclear receptor subfamily 0, group B, member 2)  
Immunohistochemical analysis of paraffin-embedded SW480 Xenograft, using NR0B2(TA308392) antibody at 1:100 dilution. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NR0B2 antibody

  Rabbit Polyclonal Anti-NR0B2 Antibody  
WB Suggested Anti-NR0B2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Transfected 293T Rabbit IgG Purified Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR0B2 antibody

  Rabbit Polyclonal Anti-NR0B2 Antibody  
WB Suggested Anti-NR0B2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Transfected 293T Rabbit IgG Purified Can, Eq, GP, Hu, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR0B2 antibody

  Rabbit Polyclonal Anti-NR0B2 Antibody  
WB Suggested Anti-NR0B2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR0B2 antibody

  Rabbit Polyclonal Anti-NR0B2 Antibody  
WB Suggested Anti-NR0B2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR0B2 antibody

  Rabbit Polyclonal Anti-NR0B2 Antibody (Ligand-binding Domain)  
Anti-NR0B2 antibody IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

NR0B2 antibody

  NR0B2 mouse monoclonal antibody, clone OTI1A2 (formerly 1A2)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR0B2 (RC206422, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NR0B2.(1:2000) Mouse IgG1 OTI1A2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR0B2 antibody

  NR0B2 mouse monoclonal antibody, clone OTI6D8 (formerly 6D8)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR0B2 (RC206422, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NR0B2.(1:2000) Mouse IgG2b OTI6D8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR0B2 antibody

  NR0B2 mouse monoclonal antibody, clone OTI2B6 (formerly 2B6)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR0B2 (RC206422, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NR0B2.(1:2000) Mouse IgG2a OTI2B6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR0B2 (Center) antibody

NR0B2 antibody (Center) (Cat. #AP52928PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NR0B2 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NR0B2 - human gene knockout kit via CRISPR

NR0B2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NR0B2 - human gene knockout kit via CRISPR

NR0B2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NR0B2 - human gene knockout kit via CRISPR

NR0B2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NR0B2 - human gene knockout kit via CRISPR

NR0B2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NR0B2 (full length, N-term HIS tag)

  Recombinant protein of human nuclear receptor subfamily 0, group B, member 2 (NR0B2), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
NR0B2 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NR0B2 overexpression lysate

NR0B2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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