NR1H3 antibody

Principal name

NR1H3 antibody

Alternative names for NR1H3 antibody

LXRA, Oxysterols receptor LXR-alpha, Liver X receptor alpha, Nuclear orphan receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3

SwissProt ID

Q13133 (Human), Q5E9B6 (Bovin), Q62685 (Rat), Q9Z0Y9 (Mouse)

Gene ID

10062 (NR1H3), 22259 (Nr1h3)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Rb (Rabbit), Ms (Mouse), Rt (Rat), Chk (Chicken), Por (Porcine), Ze (Zebrafish), Mky (Monkey), Eq (Equine), Gt (Goat), GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Electrophoretic Mobility Shift Assay (EMSA), Immunoprecipitation (IP), Flow Cytometry (F)

Background of NR1H3 antibody

Liver X receptor alpha (LXR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the transport and catabolism of cholesterol as well as fatty acid metabolism. LXR alpha also appears to be an important insulin mediating factor in the regulation of lipogenesis. LXR alpha is known to be activated by oxysterols and to regulate a wide range of genes, including members of the ATP-binding cassette (ABC) superfamily of transporter proteins (ABCA1 and ABCG1), surface constituents of plasma lipoproteins like apolipoprotein E, and cholesterol ester transport protein. The induced expression of LXR alpha may be related to foam-cell formation in atherosclerotic lesions. As a result, LXR alpha has been suggested as a potential therapeutic target for treating atherosclerosis. LXR alpha forms a heterodimer with RXR alpha and binds the DR4-type cis-element. Recently LXR alpha has been shown to act as a cAMP-responsive nuclear modulator of renin and c-myc expression, suggesting a possible involvement of LXR alpha in the cardiovascular system and in general gene transcription.

General readings

Albers,M., et al., (2006) J. Biol. Chem. 281 (8), 4920-4930

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NR1H3 antibody

  NR1H3 mouse monoclonal antibody, clone OTI1A5 (formerly 1A5)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-NR1H3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA805015)(1:150) Mouse IgG2a OTI1A5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR1H3 antibody

  Rabbit Polyclonal Antibody against Liver X Receptor  
Western Blot: LXR Antibody - WB detection of LXR in human liver. Rabbit IgG Purified Hu, Mky WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NR1H3 antibody

  Rabbit Polyclonal LXR-A Antibody  
Western blot analysis of LXR-A in rat liver tissue lysate with LXR-A antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1H3 antibody

  Anti-NR1H3 Rabbit Polyclonal Antibody  
Predicted band size: 50 kDa . Positive control: MCF7 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NR1H3 (Center) antibody

  Rabbit polyclonal NR1H3 Antibody (Center)  
Western blot analysis of NR1H3 Antibody (Center) (Cat. #TA325122) in MCF-7 cell line lysates (35ug/lane). NR1H3 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

NR1H3 antibody

  Rabbit anti-NR1H3 Polyclonal Antibody  
Western blot analysis of extracts of MCF7 cell lines, using NR1H3 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1H3 antibody

  Rabbit Polyclonal Anti-NR1H3 Antibody  
WB Suggested Anti-NR1H3 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, Gt, Hu, Por, Rb WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1H3 antibody

  Rabbit Polyclonal Anti-NR1H3 Antibody  
WB Suggested Anti-NR1H3 Antibody Titration: 0.2-1 ug/ml; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1H3 antibody

  NR1H3 mouse monoclonal antibody, clone OTI1F5 (formerly 1F5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR1H3 (RC223767, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NR1H3. Mouse IgG2b OTI1F5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

NR1H3 (C-term) antibody

Western blot with LXRα Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

NR1H3 (N-term) antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NR1H3 - human gene knockout kit via CRISPR

NR1H3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NR1H3 - human gene knockout kit via CRISPR

NR1H3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NR1H3 - human gene knockout kit via CRISPR

NR1H3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NR1H3 - human gene knockout kit via CRISPR

NR1H3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nr1h3 - mouse gene knockout kit via CRISPR

Nr1h3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nr1h3 - mouse gene knockout kit via CRISPR

Nr1h3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nr1h3 - mouse gene knockout kit via CRISPR

Nr1h3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nr1h3 - mouse gene knockout kit via CRISPR

Nr1h3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NR1H3 (transcript variant 1)

  Recombinant protein of human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1  
NR1H3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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