NR1H4 / FXR antibody

Principal name

NR1H4 / FXR antibody

Alternative names for NR1H4 / FXR antibody

Bile acid receptor, BAR, HRR1, RIP14, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14

SwissProt ID

Q3SZL0 (Bovin), Q60641 (Mouse), Q62735 (Rat), Q96RI1 (Human)

Gene ID

9971 (NR1H4), 20186 (Nr1h4), 859169 (Q8SQI1)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C)

Background of NR1H4 / FXR antibody

The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

General readings

Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, Dong B, Huang X, Moore DD.
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration.
Science. 2006 Apr 14;312(5771):233-6.
PMID: 16614213

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NR1H4 / FXR antibody

TA302484 (1µg/ml) staining of Human Lung lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1H4 / FXR antibody

Western Blot: FXR Antibody - Detection of FXR in HeLa nuclear extract using anti-FXR.  ECL 30 minute detection. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NR1H4 / FXR antibody

WB Suggested Anti-NR1H4 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1H4 / FXR antibody

WB Suggested Anti-NR1H4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1H4 / FXR antibody

NR1H4 / FXR Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

NR1H4 / FXR antibody

NR1H4 / FXR Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

NR1H4 / FXR antibody

Immunofluorescence of monoclonal antibody to NR1H4 on HepG2 cell. [antibody concentration 10 ug/ml] Mouse IgG1 1G11 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

NR1H4 / FXR antibody

Immunofluorescence of monoclonal antibody to NR1H4 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 1B10 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

NR1H4 / FXR antibody

NR1H4 polyclonal antibody ( Cat # PAB7164 ) ( 1 µg/ml ) staining of human lung lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

NR1H4 / FXR antibody

Western blot analysis of NR1H4 in HeLa nuclear extract using NR1H4 polyclonal antibody ( Cat # PAB12369 ). ECL 30 minute Western blot analysis. Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

NR1H4 / FXR antibody

Human kidney; NR1H4 antibody - middle region (ARP33672_P050) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rb, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

NR1H4 / FXR antibody

Human THP-1; WB Suggested Anti-NR1H4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: THP-1 cell lysate; NR1H4 antibody - middle region (ARP45626_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

NR1H4 / FXR antibody

NR1H4 / FXR Mouse IgG2a A9033A Purified Hu, Ms, Rt C, ELISA, P, WB
0.1 ml / €640.00
  Funakoshi Co., Ltd.

NR1H4 / FXR antibody

Western Blot: NR1H4 Antibody [NB100-55416] - NB100-55416 (1ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

NR1H4 / FXR antibody

NR1H4 / FXR Rabbit Biotin Hu WB
0.1 ml / €380.00
  Novus Biologicals Inc.

NR1H4 / FXR antibody

NR1H4 / FXR Rabbit DyLight488 Hu WB
0.1 ml / €400.00
  Novus Biologicals Inc.

NR1H4 / FXR antibody

NR1H4 / FXR Rabbit HRP Hu WB
0.1 ml / €390.00
  Novus Biologicals Inc.

NR1H4 / FXR Control Peptide

NR1H4 / FXR
50 µg / €140.00
  Novus Biologicals Inc.

NR1H4 / FXR antibody

NR1H4 / FXR Rabbit Hu WB
25 µl / €160.00
  Novus Biologicals Inc.

NR1H4 / FXR antibody

Immunohistochemistry-Paraffin: FXR Antibody [NBP1-91914] Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

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