NR1I2 antibody

Principal name

NR1I2 antibody

Alternative names for NR1I2 antibody

PXR, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PXR, Pregnane X receptor, Orphan nuclear receptor PAR1, Steroid and xenobiotic receptor

SwissProt ID

O54915 (Mouse), O75469 (Human), Q9R1A7 (Rat)

Gene ID

8856 (NR1I2)

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Mky (Monkey), Gorilla, Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of NR1I2 antibody

NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.

General readings

1. Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM.
A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 2008 Apr 452 (7187): 604-9.
PMID: 18385733

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NR1I2 (all Isoforms) antibody

TA305651 (1ug/ml) staining of HepG2 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

Western blot analysis of extracts from HeLa and 293 cells, using NR1I2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

Anti-PXR antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. Goat Purified Hu E, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

NR1I2 antibody

Host:Rabbit; Target Name:NR1I2; Sample Tissue:Human Fetal Muscle; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

WB Suggested Anti-NR1I2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Hela cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

NR1I2 Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

NR1I2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

WB Suggested Anti-NR1I2 Antibody Titration: 0.5 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Eq, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I2 (Center) antibody

Western blot analysis of NR1I2 Antibody (Center) (AP18142PU-N) in HL-60 cell line lysates (35ug/lane). NR1I2 (arrow) was detected using the purified Pab. Rabbit Hu F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

NR1I2 antibody

NR1I2 Mouse Serum Hu, Rt E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

NR1I2 antibody

NR1I2 Mouse Purified Hu, Rt E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

NR1I2 antibody

Western Blot analysis of NR1I2 expression in transfected 293T cell line (H00008856-T02) by NR1I2 MaxPab polyclonal antibody.

Lane 1: NR1I2 transfected lysate(49.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

NR1I2 antibody

Western Blot analysis of NR1I2 expression in transfected 293T cell line (H00008856-T02) by NR1I2 MaxPab polyclonal antibody.

Lane 1: NR1I2 transfected lysate(49.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

NR1I2 antibody

NR1I2 polyclonal antibody ( Cat # PAB11612 ) ( 1 µg/ml ) staining of HepG2 lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

NR1I2 antibody

Hum. Fetal Muscle; Host:Rabbit. Target Name:NR1I2. Sample Tissue:Human Fetal Muscle. Antibody Dilution: 1.0ug/ml.; NR1I2 antibody - N-terminal region (ARP36015_P050) in Hum. Fetal Muscle cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

NR1I2 antibody

Human Small Intestine; Immunohistochemistry with Human Small Intestine tissue at an antibody concentration of 5.0ug/ml using anti-NR1I2 antibody (ARP36016_P050); NR1I2 antibody - N-terminal region (ARP36016_P050) in Human Small Intestine cells using Immunohistochemistry Rabbit Aff - Purified Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

NR1I2 antibody

Human Jurkat; WB Suggested Anti-NR1I2 Antibody Titration: 5.0ug/ml. ELISA Titer: 1:12500. Positive Control: Jurkat cell lysate; NR1I2 antibody - C-terminal region (ARP39532_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

NR1I2 antibody

Human Jurkat; WB Suggested Anti-NR1I2 Antibody Titration: 0.5ug/ml. Positive Control: Jurkat cell lysate; NR1I2 antibody - N-terminal region (ARP39738_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
0.1 mg / €310.00
  AVIVA Systems Biology

NR1I2 Common antibody

NR1I2 Mouse IgG2a H4417 Purified Hu ELISA, WB
0.1 ml / €640.00
  Funakoshi Co., Ltd.

NR1I2 antibody

Detection of PXR by Western blot analysis. PXR can be detected in nuclear extracts derived from HepG2 cells (Catalog No. NB 600-1289) using PXR rabbit polyclonal antibody at a 1:1000 dilution. Rabbit IgG Aff - Purified Hu WB
50 µl / €320.00
  Novus Biologicals Inc.

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