NR1I2 antibody

Principal name

NR1I2 antibody

Alternative names for NR1I2 antibody

PXR, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PXR, Pregnane X receptor, Orphan nuclear receptor PAR1, Steroid and xenobiotic receptor

SwissProt ID

O54915 (Mouse), O75469 (Human), Q9R1A7 (Rat)

Gene ID

8856 (NR1I2), 18171 (Nr1i2), 84385

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of NR1I2 antibody

NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.

General readings

1. Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM.
A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 2008 Apr 452 (7187): 604-9.
PMID: 18385733

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NR1I2 (all Isoforms) antibody

  Goat Anti-PXR / NR1I2 Antibody  
TA305651 (1ug/ml) staining of HepG2 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

  Rabbit polyclonal anti-NR1I2 antibody  
Western blot analysis of extracts from HeLa and 293 cells, using NR1I2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

  Anti-NR1I2 Goat Polyclonal Antibody  
Anti-PXR antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. Goat Purified Hu E, P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

NR1I2 antibody

  Rabbit Polyclonal Anti-NR1I2 Antibody  
Host:Rabbit; Target Name:NR1I2; Sample Tissue:Human Fetal Muscle; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

  Rabbit Polyclonal Anti-NR1I2 Antibody  
WB Suggested Anti-NR1I2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Hela cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

  Rabbit Polyclonal Anti-NR1I2 Antibody  
NR1I2 Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

  Rabbit Polyclonal Anti-NR1I2 Antibody  
NR1I2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I2 antibody

  Rabbit Polyclonal Anti-NR1I2 Antibody  
WB Suggested Anti-NR1I2 Antibody Titration: 0.5 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Eq, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I2 (Center) antibody

Western blot analysis of NR1I2 Antibody (Center) (AP18142PU-N) in HL-60 cell line lysates (35ug/lane). NR1I2 (arrow) was detected using the purified Pab. Rabbit Hu F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NR1I2 - human gene knockout kit via CRISPR

NR1I2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NR1I2 - human gene knockout kit via CRISPR

NR1I2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NR1I2 - human gene knockout kit via CRISPR

NR1I2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NR1I2 - human gene knockout kit via CRISPR

NR1I2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nr1i2 - mouse gene knockout kit via CRISPR

Nr1i2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nr1i2 - mouse gene knockout kit via CRISPR

Nr1i2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nr1i2 - mouse gene knockout kit via CRISPR

Nr1i2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nr1i2 - mouse gene knockout kit via CRISPR

Nr1i2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NR1I2 (transcript variant 1)

  Recombinant protein of human nuclear receptor subfamily 1, group I, member 2 (NR1I2), transcript variant 1  
NR1I2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

NR1I2 overexpression lysate

NR1I2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, NR1I2 (mGFP-tagged) - Human nuclear receptor subfamily 1, group I, member 2 (NR1I2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, NR1I2 (mGFP-tagged) - Human nuclear receptor subfamily 1, group I, member 2 (NR1I2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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