NR1I3 / CAR antibody

Principal name

NR1I3 / CAR antibody

Alternative names for NR1I3 / CAR antibody

MB67, Nuclear receptor subfamily 1, group I, member 3, Constitutive androstane receptor, Constitutive activator of retinoid response, Orphan nuclear receptor MB67

SwissProt ID

Q3V008 (Mouse), Q5VTW5 (Human)

Gene ID

9970 (NR1I3), 12355

Available reactivities

Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Hu (Human), Chk (Chicken), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of NR1I3 / CAR antibody

NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size. NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

General readings

Osabe,M., (2008) Biochem. Biophys. Res. Commun. 369 (4), 1027-1033

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NR1I3 / CAR antibody

WB Suggested Anti-NR1I3 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I3 / CAR antibody

WB Suggested Anti-NR1I3 Antibody Titration: 5.0 ug/ml; Positive Control: SP2/0 cell lysate Rabbit IgG Purified Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NR1I3 / CAR antibody

Human HepG2; WB Suggested Anti-NR1I3 Antibody Titration: 1.25ug/ml. Positive Control: HepG2 cell lysate; NR1I3 antibody - C-terminal region (ARP33674_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

NR1I3 / CAR antibody

Mouse Liver; NR1I3 antibody - C-terminal region (ARP37028_T100) in Mouse Liver cells using Immunohistochemistry Rabbit Aff - Purified Ms P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

NR1I3 / CAR antibody

Mouse NIH-3T3; WB Suggested Anti-NR1I3 Antibody Titration: 2.5ug/ml. ELISA Titer: 1:312500. Positive Control: NIH/3T3 cell lysate; NR1I3 antibody - middle region (ARP37876_T100) in Mouse NIH-3T3 cells using Western Blot Rabbit Aff - Purified Bov, Can, Ms, Por, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

NR1I3 / CAR antibody

Human Liver; NR1I3 antibody - N-terminal region (ARP45623_T100) in Human Liver cells using Immunohistochemistry Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

NR1I3 / CAR antibody

Human Colon; Immunohistochemistry with Human Colon lysate tissue at an antibody concentration of 5.0ug/ml using anti-NR1I3 antibody (ARP45624_P050); NR1I3 antibody - middle region (ARP45624_P050) in Human Colon cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

7 Item(s)

per page
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