NRIP1 antibody

Principal name

NRIP1 antibody

Alternative names for NRIP1 antibody

Nuclear factor RIP140, Receptor-interacting protein 140, Nuclear receptor-interacting protein 1

SwissProt ID

P48552 (Human)

Gene ID

8204 (NRIP1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P)

Background of NRIP1 antibody

The nuclear receptor transcriptional activity is regulated by coregulators such as receptor interacting protein 140 (RIP140) by providing an bridging apparatus between nuclear receptor and the transcription machinery. It has recently been shown that Orphan receptor SF-1, which regulates the cAMP stimulated expression of human steroidenic acute regulatory protein gene DAX-1, interacts with RIP140 (1). RIP140 also regulated the target gene expression in response to corticosteroid hormone receptor (glucocorticoid receptor, GR) stimulation. The ligand binding domain of the GR receptor is sufficient for the RIP140 interaction. It has been suggested that both N and C terminal regions of the RIP140 interacts and binds to the GR receptor, thereby modulate the transactivation transcriptional activity of the receptor (2). RIP140 encodes a histone deactylase (HDAC) inhibitor–sensitive responsive activity (3). These interactions are the result of direct contact of RIP140 and HDAC1 and HDAC-2. The HDAC interaction domain is mapped to its N-terminal domain between amino acid 78 and 303 (3). Cloned RIP140 is a 4307 bp long and the deduced amino acid sequence contain a 1161 amino acid nuclear protein (MW 140 kDa) including a putative HDAC domain near the N-terminal region of the protein. RIP 140 is widely expressed in nuclear fractions of most of the glucocorticoid responsive cells including CNS, adrenals, kidney etc.

General readings

General / background references:Treuter E et al. A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol 12:864-81 (1998). PubMed PMID: 9626662
Joyeux A et al. RIP 140 enhances nuclear receptor-dependent transcription in vivo in yeast. Mol Endocrinol 11:193-202 (1997). PubMed PMID: 9013766
Mangelsdorf DJ & Evans RM The RXR heterodimers and orphan receptors. Cell 83:841-50 (1995). PubMed PMID: 8521508
Cavailles V et al. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J 14:3741-51 (1995). PubMed PMID: 7641693

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NRIP1 antibody

TA305768 (0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

NRIP1 antibody

ELISA: RIP140 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

NRIP1 (N-term) antibody

NRIP1 Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

NRIP1 antibody

NRIP1 Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

NRIP1 (C-term) antibody

NRIP1 Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

NRIP1 antibody

NRIP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

NRIP1 antibody

ELISA: RIP140 Antibody [32260002] Rabbit Hu E
50 µg / €500.00
  Novus Biologicals Inc.

NRIP1 antibody

Western Blot: RIP 140 Antibody [NB110-5122] - Figure 1 shows a Western blot of recombinant human RIP 140 using NB110-5122. Rabbit IgG Aff - Purified Hu ICC/IF, IP, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

NRIP1 antibody

Western Blot: RIP140 Antibody [NBP1-36750] - (0.5µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

NRIP1 / NRIP2 / NRIP3 Control Peptide

NRIP1 / NRIP2 / NRIP3
0.25 mg / €250.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NRIP1

NRIP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

NRIP1

NRIP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

per page
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