NTF2 antibody

Principal name

NTF2 antibody

Alternative names for NTF2 antibody

NTF-2, NUTF2, Nuclear transport factor 2

SwissProt ID

P61970 (Human)

Gene ID

10204 (NUTF2)

Available reactivities

Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Xen (Xenopus), Chk (Chicken), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Neutralisation (NEUT), Paraffin Sections (P)

Background of NTF2 antibody

NTF2 (nuclear transport factor 2, also known as p10) an evolutionarily conserved protein that is essential for growth in yeast, plays an important role in nuclear protein import and Ran regulation. The properties of NTF2 suggest it may modulate the steady-state distribution of Ran. Both are imported into the nucleus as stoichiometric components of the import complex, and are required for efficient import. NTF2 regulates Ran distribution in living cells, and NTF2-mediated Ran nuclear import is required for NLS-dependent protein import in vitro. NTF2 binds directly to RanGDP but not RanGTP. In addition to binding RanGDP, NTF2 also binds NPC proteins. Mutations in NTF2 that abolish Ran binding do not affect binding to NPC proteins, which suggests that Ran and NPC proteins bind to different domains of NTF2. NTF2 binds directly to p62, as well as to other NPC proteins containing multiple FxFG peptide repeats. These repeat-containing NPC proteins have been proposed to provide binding sites for import complexes during translocation through the NPC.

General readings

General / background references:Steggerda SM et al. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. Mol Biol Cell 11:703-19 (2000). PubMed PMID: 10679025
Nakielny S & Dreyfuss G Transport of proteins and RNAs in and out of the nucleus. Cell 99:677-90 (1999). PubMed PMID: 10619422
Mattaj IW & Englmeier L Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 67:265-306 (1998). PubMed PMID: 9759490

10 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NTF2 antibody

WB Suggested Anti-NUTF2 Antibody; Titration: 1.0 ug/ml; Positive Control: ACHN Whole Cell NUTF2 is supported by BioGPS gene expression data to be expressed in ACHN Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

NTF2 antibody

NTF2 Mouse IgG2b 4F5 Aff - Purified Chk, Hu, Mky, Ms, Rt, Xen E, ICC/IF, IP, NEUT, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

NTF2 antibody

Immunohistochemistry-Paraffin: NTF2 Antibody [NBP1-82520] - Immunohistochemical staining of human bronchus shows strong cytoplasmic and membranous positivity in respiratory epithelial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

NTF2 antibody

Immunohistochemistry-Paraffin: NTF2 Antibody [NBP1-82521] Immunohistochemical staining of human stomach, upper shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NTF2

NTF2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

NTF2 (1-127, His-tag)

NTF2 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

NTF2 (1-127, His-tag)

NTF2 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

NTF2

NTF2 Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

NTF2

NTF2 Human Purified
0.1 mg / €340.00
  Novus Biologicals Inc.

NTF2

NTF2 Human Purified
0.5 mg / €760.00
  Novus Biologicals Inc.

10 Item(s)

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