Nuclear pore protein NSP1 antibody

Principal name

Nuclear pore protein NSP1 antibody

Alternative names for Nuclear pore protein NSP1 antibody

Nucleoskeletal-like protein, p110, YJL041W, J1207

SwissProt ID

P14907 (Yeast)

Gene ID

853409 (NSP1)

Ncbi ID

NP_012494, 4932

Available reactivities

Ye (Yeast)

Available hosts

Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB)

Background of Nuclear pore protein NSP1 antibody

The Nuclear pore complex (NPC) has a molecular mass of approx. 125 KDa in vertebrates and contains about 50 or more different proteins . The NPC spans the dual membrane of the the nuclear envelope (NE) and acts as a gateway for macromolecular traffic between the cytoplasm and the nucleus. The basic framework of the NPC consists of a central core with a ring-spoke structure exhibiting 8 fold radial symmetry. From this central ring 50 to 100 nm fibrils extend into the nucleoplasm and the cytoplasm. The NPC is in turn anchored in the NE by the nuclear lamina, a meshwork of lamins and lamin-associated proteins that forms a 15 nm thick fibrous structure between the inner nuclear membrane and peripheral chromatin. A number of proteins called nucleoporins have been localized to discrete regions of the NPC and are often used as markers for this compartment, e.g. Nup153. Approximately half of the nucleoporins (or Nups) contain a phenyalanine-glycine repeat motif (FG repeat), which may be diagnostic for proteins playing a role in nuclear transport.

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