Nucleophosmin antibody

Principal name

Nucleophosmin antibody

Alternative names for Nucleophosmin antibody

NPM, NPM1, Numatrin, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38

SwissProt ID

P06748 (Human), Q61937 (Mouse)

Gene ID

4869 (NPM1), 6448692 (acpP)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Do (Dolphin), Chk (Chicken), Xen (Xenopus), Rb (Rabbit), Dky (Donkey), Hst (Hamster), Chimp (Chimpanzee), Mky (Monkey)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Nucleophosmin antibody

Nucleophosmin (NPM) also called B23, nutramin and NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus and cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperone activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division).
Because of NPM gene interaction with several tumor-associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins.

General readings

General / background references:Chan PK et al. Amino acid sequence of a specific antigenic peptide of protein B23. J Biol Chem 261:14335-41 (1986). PubMed PMID: 2429957
Yung BY et al. Translocation of nucleolar phosphoprotein B23 (37 kDa/pI 5.1) induced by selective inhibitors of ribosome synthesis. Biochim Biophys Acta 826:167-73 (1985). PubMed PMID: 3907710
Ochs R et al. Localization of nucleolar phosphoproteins B23 and C23 during mitosis. Exp Cell Res 146:139-49 (1983). PubMed PMID: 6345184

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Nucleophosmin (81-294) antibody

Immunohistochemistry: SM6037 NPM antibody staining of Paraffin-Embedded Human Palatine Tonsil Tissue at 1/100 dilution. Mouse IgG2b 5E3 Purified Hu E, F, ICC/IF, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Nucleophosmin (81-294) antibody

Immunohistochemistry: SM6037 NPM antibody staining of Paraffin-Embedded Human Palatine Tonsil Tissue at 1/100 dilution. Mouse IgG2b 5E3 Purified Hu E, F, ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

Nucleophosmin antibody

Human Lung; NPM1 antibody - N-terminal region (ARP34094_T100) in Human Lung cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Nucleophosmin (C-term) antibody

TA303008 staining (0.1µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Chimp, Hu, Ms, Rt E, WB
20 µg / €200.00
  Acris Antibodies GmbH

Nucleophosmin antibody

Detection of mutant nucleophosmin in OCI-AML3 lysates Rabbit IgG Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Nucleophosmin (C-term) antibody

TA303008 staining (0.1µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Chimp, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nucleophosmin (C-term) antibody

NPM1 Antibody (C-term) (Cat. #TA324742) western blot analysis in Hela,Jurkat cell line lysates (35ug/lane).This demonstrates the NPM1 antibody detected the NPM1 protein (arrow). Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Nucleophosmin antibody

NPM1 Antibody (Cat. #TA325171) western blot analysis in Hela,Jurkat,MCF-7,mouse NIH/3T3 cell line lysates (35ug/lane).This demonstrates the NPM1 antibody detected the NPM1 protein (arrow). Mouse IgG1 1042CT5.2.1 Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Nucleophosmin antibody

Western blot analysis of NPM expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Nucleophosmin antibody

Western blot detection of NPM1 in Hela,Jurkat and 3T3 cell lysates using NPM1 mouse mAb (1:1000 diluted).Predicted band size:33KDa.Observed band size:38KDa. Mouse IgG1 2D9-C3-E5 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Nucleophosmin antibody

Western blot analysis on HeLa cell lysate using NPM Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nucleophosmin antibody

ELISA: Nucleophosmin Antibody - Affinity Purified Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Nucleophosmin antibody

Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissues, showing nuclear localization using NPM antibody Cat.-No AM06071SU-N with DAB staining. Mouse IgG1 7H10B9 Ascites Hu, Mky ICC/IF, P, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

Nucleophosmin antibody

Nucleophosmin Mouse IgG1 No-185 Supernatant Chk, Pleurodelis, Triturus., Xen C, ICC/IF, IP, WB
0.25 ml / €340.00
  Acris Antibodies GmbH

Nucleophosmin antibody

Human tonsil stained with anti-Nucleophosmin Antibody Cat.-No AM33222PU (Clone SP 236). Rabbit IgG SP236 Purified Bov, Chk, Hu, Ms, Rt F, P
0.5 ml / €500.00
  Acris Antibodies GmbH

Nucleophosmin antibody

Human tonsil stained with anti-Nucleophosmin Antibody Cat.-No AM33222PU (Clone SP 236). Rabbit IgG SP236 Purified Bov, Chk, Hu, Ms, Rt F, P
1 ml / €710.00
  Acris Antibodies GmbH

Nucleophosmin antibody

Human tonsil stained with anti-Nucleophosmin Antibody Cat.-No AM33222PU (Clone SP 236). Rabbit IgG SP236 Purified Bov, Chk, Hu, Ms, Rt F, P
0.1 ml / €290.00
  Acris Antibodies GmbH

Nucleophosmin antibody

Nucleophosmin Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Nucleophosmin pThr234/Thr237 antibody

AP07468PU-N Nucleophosmin antibody staining of Formalin-Fixed Paraffin-Embedded Human Skin at 1/50 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Nucleophosmin pThr199 antibody

AP07469PU-N Nucleophosmin antibody staining of Formalin-Fixed Paraffin-Embedded Human Thymus at 1/50 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

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