NUDT15 antibody

Principal name

NUDT15 antibody

Alternative names for NUDT15 antibody

MTH2, MutT homolog 2, Nudix motif 15, Probable 8-oxo-dGTP diphosphatase NUDT15, 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15, Nucleoside diphosphate-linked moiety X motif 15

SwissProt ID

Q8BG93 (Mouse), Q9NV35 (Human)

Gene ID

55270 (NUDT15)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of NUDT15 antibody

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.

General readings

Hori, M., et al. Free Radic. Biol. Med. 48(9):1197-1201 (2010)
Yu, Y., et al. J. Biol. Chem. 284(29):19310-19320 (2009)
Dunham, A., et al. Nature 428(6982):522-528 (2004)
Cai, J.P., et al. Biochem. Biophys. Res. Commun. 305(4):1073-1077 (2003)

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NUDT15 (C-term) antibody

Immunohistochemistry analysis in human breast tissuee (Formalin-fixed, Paraffin-embedded) using NUDT15 antibody Cat.-No. AP52959PU-N (C-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the NUDT15 antibody  for IHC. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

NUDT15 antibody

Immunohistochemistry-Paraffin: NUDT15 Antibody [NBP1-83800] - Immunohistochemical staining of human breast shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

NUDT15

NUDT15 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

NUDT15 overexpression lysate

NUDT15 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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