NUP98 / ADAR2 antibody

Principal name

NUP98 / ADAR2 antibody

Alternative names for NUP98 / ADAR2 antibody

Nuclear pore complex protein Nup98-Nup96

SwissProt ID

P49793 (Rat), P52948 (Human), Q9Y6J4 (Human)

Gene ID

4928 (NUP98)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), Por (Porcine), Rb (Rabbit), GP (Guinea Pig), Ye (Yeast)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot), Immunocytochemistry (ICC), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of NUP98 / ADAR2 antibody

The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

General readings

Pan,Q., (2008) Oncogene 27 (24), 3414-3423

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

NUP98 / ADAR2 antibody

  Mouse Monoclonal NUP98 Antibody  
Western blot detection of NUP98 in Hela,Jurkat and MCF7 cell lysates using NUP98 mouse mAb (1:1000 diluted).Predicted band size: 98kDa.Observed band size: 98kDa. Mouse IgG1 3B8-D7-H10 Purified WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

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