OAS1 / OIAS antibody

Principal name

OAS1 / OIAS antibody

Alternative names for OAS1 / OIAS antibody

2'-5'-oligoadenylate synthetase 1, p46/p42 OAS, (2-5')oligo(A) synthetase 1, 2-5A synthetase 1

SwissProt ID

P00973 (Human), Q05961 (Rat), Q29599 (Pig)

Gene ID

4938 (OAS1), 192281 (Oas1a)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rt (Rat), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of OAS1 / OIAS antibody

OAS1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2\'-specific nucleotidyl transfer reactions to synthesize 2\',5\'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Mutations in this gene have been associated with host susceptibility to viral infection.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2\'-specific nucleotidyl transfer reactions to synthesize 2\',5\'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

General readings

Rios JJ., et al. (2007) BMC Genomics. 8:313.
Tessier MC., et al. (2006) J Med Genet. 43(2):129-32.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

OAS1 / OIAS (Isoforms 1) antibody

  Goat Anti-OAS1 Antibody  
TA326756 (1µg/ml) staining of HepG2 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

OAS1 / OIAS antibody

  Rabbit Polyclonal Anti-OAS1 Antibody  
WB Suggested Anti-OAS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: 293T cell lysateOAS1 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

OAS1 / OIAS antibody

  Rabbit Polyclonal Anti-OAS1  
WB Suggested Anti-OAS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

OAS1 / OIAS antibody

  Rabbit Polyclonal Anti-OAS1  
WB Suggested Anti-OAS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human heart Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

OAS1 / OIAS antibody

  Rabbit Polyclonal Anti-OAS1 Antibody  
WB Suggested Anti-OAS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Stomach Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

OAS1 / OIAS antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 2D4 Hu E, P
50 µg / €530.00
  Acris Antibodies GmbH

OAS1 / OIAS (317-331) antibody

Formalin-Fixed Paraffin-Embedded Human Colon stained with anti-OAS1 Antibody Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

OAS1 / OIAS (C-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

OAS1 - human gene knockout kit via CRISPR

OAS1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

OAS1 - human gene knockout kit via CRISPR

OAS1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

OAS1 - human gene knockout kit via CRISPR

OAS1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

OAS1 - human gene knockout kit via CRISPR

OAS1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

OAS1 / OIAS (transcript variant 2)

  Recombinant protein of human 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1), transcript variant 2  
OAS1 / OIAS Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

OAS1 / OIAS (1-364, His-tag)

OAS1 / OIAS Human Purified > 95 % by SDS – PAGE E. coli
0.5 mg / €1,500.00
  Acris Antibodies GmbH

OAS1 / OIAS (1-364, His-tag)

OAS1 / OIAS Human Purified > 95 % by SDS – PAGE E. coli
0.1 mg / €520.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

OAS1 overexpression lysate

OAS1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

OAS1 overexpression lysate

OAS1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

OAS1 overexpression lysate

OAS1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, OAS1 (mGFP-tagged) - Human 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, OAS1 (mGFP-tagged) - Human 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Lenti ORF particles, OAS1 (mGFP-tagged) - Human 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, OAS1 (mGFP-tagged) - Human 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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