OAZ2 antibody

Principal name

OAZ2 antibody

Alternative names for OAZ2 antibody

Ornithine decarboxylase antizyme 2, ODC-Az 2, AZ2

SwissProt ID

O08608 (Mouse), O95190 (Human)

Gene ID

4947 (OAZ2), 18247 (Oaz2)

Available reactivities

Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog, Eq (Equine)

Available hosts


Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of OAZ2 antibody

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family, and like antizyme 1, it has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation in vivo, as well as by inhibiting polyamine uptake. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutiory more conserved, suggesting that it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Altertively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014].

General readings

Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)
Mangold, U., et al. Biochem. J. 385 (PT 1), 21-28 (2005)
Chen, H., et al. J. Biol. Chem. 277(48):45957-45961(2002)
Coffino, P. Proc. Natl. Acad. Sci. U.S.A. 97(9):4421-4423(2000)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

OAZ2 antibody

  Rabbit Polyclonal Anti-OAZ2 Antibody  
WB Suggested Anti-OAZ2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Liver Rabbit IgG Purified Bov, Eq, Hu, Ms, Por, Rt WB
50 µg / €360.00
  OriGene Technologies, Inc.

OAZ2 (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma reacted with OAZ2 Antibody (C-term) Cat.-No AP52982PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  OriGene Technologies GmbH

2 Item(s)

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