OGG1 antibody

Principal name

OGG1 antibody

Alternative names for OGG1 antibody

MMH, MUTM, OGH1, N-glycosylase/DNA lyase

SwissProt ID

O08760 (Mouse), O15527 (Human), O70249 (Rat), P53397 (Yeast), Q9V3I8 (Drome)

Gene ID

4968 (OGG1), 18294 (Ogg1), 81528

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse

Available applications

Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of OGG1 antibody

8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently release the 8-hydroxyguanine opposite the pyrimidine from DNA and cleave the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26.2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer. Recent work has demonstrated that Ogg plays an important role in CAG expansion, a characteristic of several neurodegenerative diseases. Ogg appears to be responsible for progressive expansion of poly-Q tracts in response to oxidative damage. Thus, Ogg provides a direct link between DNA damage and toxicity in neurons.

General readings

Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature. 2007 May 24;447(7143):447-52. Epub 2007 Apr 22. PMID: 17450122

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

OGG1 antibody

Western Blot: Ogg1 antibody - 1, 5, 10 ng titration of human recombinant Ogg1 protein, detected by anti-Ogg1. Rabbit Purified Hu, Prim, Rt C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

OGG1 antibody

TA305839 (0.1ug/ml) staining of Rat Spleen lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

OGG1 antibody

Predicted band size: 39 kDa . Positive control: Human heart tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

OGG1 antibody

Figure 1. Immunohistochemical analysis of Formalin-Fixed Paraffin-Embedded Kidney tissue using AP08789PU-N at 2.5 µg/ml. Goat IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

OGG1 (C-term) antibody

Western blot analysis of OGG1 Antibody (C-term) (AP17606PU-N) in Hela, NIH-3T3 cell line lysates (35ug/lane). OGG1 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

OGG1 antibody

Immunofluorescence of purified MaxPab antibody to OGG1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

OGG1 antibody

OGG1 MaxPab rabbit polyclonal antibody. Western Blot analysis of OGG1 expression in Jurkat. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

OGG1 antibody

Western Blot analysis of OGG1 expression in transfected 293T cell line (H00004968-T01) by OGG1 MaxPab polyclonal antibody.

Lane 1: OGG1 transfected lysate(36.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

OGG1 antibody

The Ogg1 polyclonal antibody ( Cat # PAB7311 ) ( 0.1 µg/ml ) staining of rat spleen lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Rt E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

OGG1 antibody

Immunohistochemical staining of OGG1 on formaldehyde fixed frozen sections of the substantia nigra from a Rhesus macaque with OGG1 polyclonal antibody ( Cat # PAB12085 ). Photo courtesy of Glen Kisby, Oregon Health Sciences University. The tissue was a generous gift of Dr. Steven Kohama, Oregon National Primate Research Center. Rabbit Hu, Rt C, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

OGG1 antibody

OGG1 Rabbit IgG Biotin Hu, Prim, Rt C, P, WB
0.1 ml / €400.00
  Neuromics Antibodies

OGG1 antibody

OGG1 Rabbit IgG HRP Hu, Prim, Rt C, P, WB
0.1 ml / €400.00
  Neuromics Antibodies

OGG1 antibody

OGG1 Rabbit Aff - Purified Hu, Mky, Rt C, P, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

OGG1 antibody

OGG1 Rabbit DyLight488 Hu, Mky, Rt C, P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

OGG1 antibody

OGG1 Rabbit Aff - Purified Hu, Mky, Rt C, P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

OGG1 Control Peptide

OGG1
50 µg / €140.00
  Novus Biologicals Inc.

OGG1 antibody

OGG1 Rabbit Aff - Purified Hu, Mky, Ms, Rt C, IP, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

OGG1 antibody

NB100-61664 (0.1ug/ml) staining of Rat Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat IgG Aff - Purified Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

OGG1 (transcript variant 1a)

OGG1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

OGG1 (full length, N-term HIS tag, transcript variant 2a)

OGG1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

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