OLIG2 antibody

Principal name

OLIG2 antibody

Alternative names for OLIG2 antibody

OLIG2, BHLHB1, PRKCBP2, RACK17, Oligodendrocyte transcription factor 2, Oligo2, bHLHB1, Class B basic helix-loop-helix protein 1, Protein kinase C-binding protein RACK17, Protein kinase C-binding protein 2

SwissProt ID

Q13516 (Human), Q90XB3 (Chick), Q9EQW6 (Mouse)

Gene ID

10215 (OLIG2), 50913 (Olig2)

Available reactivities

Hu (Human), Chk (Chicken), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Goat, Rabbit, Mouse, Sheep

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), EPair for Elisa (EPair)

Background of OLIG2 antibody

OLIG2 is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. OLIG2 is an essential regulator of ventral neuroectodermal progenitor cell fate. It is associated with T-cell acute lymphoblastic leukemia due to a chromosomal translocation t(14;21)(q11.2;q22). OLIG2 might play a role in learning deficits associated with Down syndrome.This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Ligon, K.L., et al., The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol, 2004. 63(5): p. 499-509.
2. Arnett, H.A., et al., bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science, 2004. 306(5704): p. 2111-5.
3. Sun, T., et al., Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci, 2003. 23(29): p. 9547-56.
4. Liu, Y. and M.S. Rao, Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord. Glia, 2004. 45(1): p. 67-74.
5. Mokhtari, K., et al., Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification. Neuropathol Appl Neurobiol, 2005. 31(1): p. 62-9.
6. Liu, R., et al., Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor.
Development, 2003. 130(25): p. 6221-31.
7. Fogarty, M., W.D. Richardson, and N. Kessaris, A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord. Development, 2005. 132(8): p.1951-9.
8. Aguirre, A.A., et al., NG2-expressing cells in the subventricular zone are type C-like cells and contribute to interneuron generation in the postnatal hippocampus. J Cell Biol, 2004. 165(4): p. 575-89.
9. Brazel, C.Y., et al., Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain. Aging Cell, 2005. 4(4): p. 197-207.
10. Kessaris, N., et al., Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development, 2004. 131(6): p. 1289-98.
11. Hu, X., et al., mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia, 2005. 7(4): p. 356-68.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

OLIG2 antibody

Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~ 32k Olig2 protein. Rabbit IgG Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

OLIG2 antibody

Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in a subset of glial cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

OLIG2 antibody

Immunohistochemical analysis of paraffin-embedded muscle tissues using OLIG2 antibody Cat.-No AM06579SU-N with DAB staining. Mouse IgG1 1G11 Ascites Hu E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

OLIG2 antibody

WB Suggested Anti-OLIG2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

OLIG2 antibody

OLIG2 Antibody - C-terminal region  validated by WB using Fetal Lung cell lysate at 1.0ug/ml. Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

OLIG2 antibody

Western blot detection of OLIG2 in CHO-K1 cell lysate(B)and CHO-K1 transfected by EGFP-OLIG2 fragment(A)cell lysate using OLIG2 mouse mAb (1:1000 diluted). Mouse IgG1 7A1-B12-G4 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

OLIG2 antibody

Western blot analysis of OLIG2 in EL4 cell lysate with OLIG2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

OLIG2 antibody

Human Brain, Oligodendroglia: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3C9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

OLIG2 antibody

OLIG2 Rabbit Purified
0.1 mg / €420.00
  Acris Antibodies GmbH

OLIG2 antibody

OLIG2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

OLIG2 pSer147 antibody

OLIG2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

OLIG2 antibody

Western Blot analysis of OLIG2 expression in transfected 293T cell line (H00010215-T01) by OLIG2 MaxPab polyclonal antibody.

Lane 1: OLIG2 transfected lysate(35.53 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

OLIG2 antibody

OLIG2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

OLIG2 antibody

Immunoprecipitation of OLIG2 transfected lysate using anti-OLIG2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with OLIG2 MaxPab mouse polyclonal antibody (B01) (H00010215-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

OLIG2 antibody

Western Blot analysis of OLIG2 expression in transfected 293T cell line (H00010215-T01) by OLIG2 MaxPab polyclonal antibody.

Lane 1: OLIG2 transfected lysate(32.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

OLIG2 antibody

OLIG2 Mouse IgG2a 3D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

OLIG2 antibody

Immunoperoxidase of monoclonal antibody to OLIG2 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Mouse IgG2a 3C9 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

OLIG2 antibody

OLIG2 Mouse IgG2a 2A8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

OLIG2 antibody

OLIG2 Mouse IgG2a 2B11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

OLIG2 antibody

human LCL and mouse brains; . Sample Type: Human Optic Nerve and Spinal CordCellular Target: Oligoden Drocyte Lineage Cells. Dilution:. 1:500; OLIG2 antibody - N-terminal region (ARP31464_P050) in human LCL and mouse brains cells using Immunohistochemistry Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

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