OLR1 / LOX1 antibody

Principal name

OLR1 / LOX1 antibody

Alternative names for OLR1 / LOX1 antibody

LOX-1, Ox-LDL receptor 1, Ox-LDL receptor 1 soluble form, sLOX1, sLOX-1, CLEC8A, Oxidized low-density lipoprotein receptor 1, Lectin-type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, C-type lectin domain family 8 member A

SwissProt ID

O70156 (Rat), P78380 (Human), P79391 (Bovin), Q9EQ09 (Mouse), Q9TTK7 (Pig), Q9XTA8 (Rabit)

Gene ID

4973 (OLR1), 108078 (Olr1), 140914

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Sheep, Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Paraffin Sections (P)

Background of OLR1 / LOX1 antibody

LOX-1 is a single-pass type II membrane protein (~45 kDa) and belongs to the C-type lectin-like protein superfamily. LOX-1 is expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain aortic intima, bone marrow, spinal cord and substantia nigra. It is also expressed on the surface of dendritic cells.
This unique scavenger receptor LOX-1 plays important roles in atherogenesis. LOX-1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis, inducing vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. LOX-1 associates with oxLDL inducing the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, LOX-1 acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. LOX-1 is involved in the inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. LOX-1 also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
The LOX-1 gene is a so-called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX-1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF-alpha, TGF-beta, and ANG II in vitro, and several proatherogenic factors in vivo.

General readings

Cominacini L. et al. (2000) J. Biol. Chem. 275: 12633-12638.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

OLR1 / LOX1 (N-term) antibody

  Rabbit polyclonal anti-LOX-1 antibody  
Western blot analysis of LOX-1 expression in Jurkat cell lysate. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

OLR1 / LOX1 antibody

  Anti-OLR1 Rabbit Polyclonal Antibody  
Predicted band size: 31 kDa . Positive control: Mouse brain and lung tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lane1: Mouse brain tissue lysate Lane2: Mouse lung tissue lysate Lysates: 40 ug per lane Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

OLR1 / LOX1 antibody

  Rabbit anti-OLR1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using OLR1 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

OLR1 / LOX1 antibody

  Rabbit Polyclonal Anti-OLR1 Antibody  
Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Human placenta tissue, Primary antibody: (OLR1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

OLR1 / LOX1 antibody

  Rabbit Polyclonal Anti-OLR1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (OLR1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

OLR1 / LOX1 (71-273) antibody

OLR1 / LOX1 Mouse IgG1 23C11 Biotin Hu, Ms FN, ICC/IF
50 µg / €340.00
  Acris Antibodies GmbH

OLR1 / LOX1 (71-273) antibody

OLR1 / LOX1 Mouse IgG1 23C11 FITC Hu, Ms FN, ICC/IF
0.1 mg / €500.00
  Acris Antibodies GmbH

OLR1 / LOX1 (71-273) antibody

OLR1 / LOX1 Mouse IgG1 23C11 Purified Hu, Ms FN, ICC/IF
0.1 mg / €460.00
  Acris Antibodies GmbH

OLR1 / LOX1 (C-term) antibody

Immunofluorescence staining of transfected Human LOX1 in 4% paraformaldehyde-fixed HeLa cells using Rabbit anti-Human LOX1 (extracellular domain) serum at 1/100. Secondary antibody was Goat anti-Rabbit Alexa Fluor 594. Rabbit Serum Hu E, ICC/IF
0.1 ml / €300.00
  Acris Antibodies GmbH

OLR1 / LOX1 (N-term) antibody

Immunofluorescence staining of transfected Human LOX1 in 4% paraformaldehyde-fixed HeLa cells using Rabbit anti-Human LOX1 serum at 1/100. Secondary antibody was Goat anti-Rabbit Alexa Fluor 594. Rabbit Serum Hu E, ICC/IF
0.1 ml / €300.00
  Acris Antibodies GmbH

OLR1 / LOX1 (N-term) antibody

AP33494PU-N (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

OLR1 / LOX1 antibody

Staining Human Umbilical Vein Endothelial Cells with Sheep anti-LOX-1 Antibody Cat.-No SP2139P Sheep Purified Hu C, F, IP, WB
50 µg / €490.00
  Acris Antibodies GmbH

OLR1 / LOX1 (sLOX-1) antibody

OLR1 / LOX1 Mouse IgG1 LOX19-22 Purified Hu E, WB
1 mg / €510.00
  HyTest Ltd.

OLR1 / LOX1 (sLOX-1) antibody

OLR1 / LOX1 Mouse IgG2a LOX20-7 Purified Hu E, WB
1 mg / €510.00
  HyTest Ltd.

OLR1 / LOX1 (sLOX-1) antibody

OLR1 / LOX1 Mouse IgG1 LOX20-15 Purified Hu E, WB
1 mg / €510.00
  HyTest Ltd.

CRISPR

Catalog No. Species Donor Vector  

OLR1 - human gene knockout kit via CRISPR

OLR1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

OLR1 - human gene knockout kit via CRISPR

OLR1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

OLR1 - human gene knockout kit via CRISPR

OLR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Olr1 - mouse gene knockout kit via CRISPR

Olr1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Olr1 - mouse gene knockout kit via CRISPR

Olr1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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