Optineurin / HIP7 antibody

Principal name

Optineurin / HIP7 antibody

Alternative names for Optineurin / HIP7 antibody

FIP-2, FIP2, GLC1E, HYPL, NRP, NEMO-related protein,Huntingtin-interacting protein 7, Optic neuropathy-inducing protein, E3-14.7K-interacting protein, Huntingtin-interacting protein L, Huntingtin yeast partner L, Transcription factor IIIA-interacting protein

SwissProt ID

Q5M7B7 (Xenla), Q7YS99 (Pig), Q8K3K8 (Mouse), Q8R5M4 (Rat), Q90Z16 (Chick), Q96CV9 (Human)

Gene ID

10133 (OPTN)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Ze (Zebrafish), African clawed frog, Mky (Monkey), Eq (Equine), Gorilla, GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of Optineurin / HIP7 antibody

OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Altertive splicing results in multiple transcript variants encoding the same protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Optineurin / HIP7 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-OPTN rabbit polyclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA590464) Rabbit IgG Purified Can, Hu, Mky, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 (575-591) antibody

Anti-Optineurin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Hela cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

Western blot analysis of extracts of various cell lines, using OPTN antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

Optineurin / HIP7 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 (115-130) antibody

Adrenal: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Mky, Prim P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Optineurin / HIP7 antibody

Immunofluorescence of purified MaxPab antibody to OPTN on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

Optineurin / HIP7 antibody

Immunofluorescence of purified MaxPab antibody to OPTN on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Optineurin / HIP7 antibody

Optineurin / HIP7 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Optineurin / HIP7 antibody

Western Blot analysis of OPTN expression in transfected 293T cell line (H00010133-T02) by OPTN MaxPab polyclonal antibody.

Lane 1: OPTN transfected lysate(65.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Optineurin / HIP7 antibody

Human HeLa; WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Hela cell lysate; OPTN antibody - N-terminal region (ARP32292_P050) in Human HeLa cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Optineurin / HIP7 antibody

Transfected 293T; WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Transfected 293T; OPTN antibody - N-terminal region (ARP39525_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Por WB
50 µg / €350.00
  AVIVA Systems Biology

Optineurin / HIP7 antibody

Human MCF-7; WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: MCF7 cell lysate; OPTN antibody - C-terminal region (ARP43601_P050) in Human MCF-7 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Optineurin / HIP7 antibody

Western Blot: Optineurin Antibody [28450002] - Samples:  Lane 1, Marker [kDa]: 250, 130, 95, 72, 55, 36, 28, 17, 11  Lane 2, RT-4  Lane 3, U-251MG sp  Lane 4, Human Plasma  Lane 5, Liver  Lane 6, Tonsil ,  Target weight [kDa]:  66, 65 (splice variants)   Validation score:  2   Validation description:  Supportive - Band of predicted size in kDa (+/-20%) with additional bands present. Rabbit Hu E, P, WB
50 µg / €500.00
  Novus Biologicals Inc.

Optineurin / HIP7 antibody

Western Blot: Optineurin Antibody [NB100-97837] - Detection of Human Optineurin by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibodies: Affinity purified  rabbit anti-Optineurin antibody NB100-97837 used for IP at 3  mcg/mg lysate. Optineurin was also immunoprecipitated by  rabbit anti-Optineurin antibodies NB100-97838 and NB100-97839,  which recognize downstream epitopes. Detection: Chemiluminescence with  an exposure time of 30 seconds. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Optineurin / HIP7 antibody

Western Blot: Optineurin Antibody [NB100-97838] - Detection of Human Optineurin by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibodies: Affinity purified  rabbit anti-Optineurin antibody NB100-97838 used for IP at 3  mcg/mg lysate. Optineurin was also immunoprecipitated by  rabbit anti-Optineurin antibodies NB100-97837 and NB100-97839,  which recognize other epitopes. Detection: Chemiluminescence with an exposure  time of 30 seconds. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Optineurin / HIP7 antibody

Immunohistochemistry-Paraffin: Optineurin Antibody [NBP1-84682] - Immunohistochemical staining of human oral mucosa shows strong cytoplasmic positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Optineurin / HIP7 antibody

Immunohistochemistry-Paraffin: Optineurin Antibody [NBP1-84683] - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Optineurin / HIP7 (transcript variant 1)

Optineurin / HIP7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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