Optineurin / HIP7 antibody

Principal name

Optineurin / HIP7 antibody

Alternative names for Optineurin / HIP7 antibody

FIP-2, FIP2, GLC1E, HYPL, NRP, NEMO-related protein,Huntingtin-interacting protein 7, Optic neuropathy-inducing protein, E3-14.7K-interacting protein, Huntingtin-interacting protein L, Huntingtin yeast partner L, Transcription factor IIIA-interacting protein

SwissProt ID

Q5M7B7 (Xenla), Q7YS99 (Pig), Q8K3K8 (Mouse), Q8R5M4 (Rat), Q90Z16 (Chick), Q96CV9 (Human)

Gene ID

10133 (OPTN), 71648 (Optn), 246294

Available reactivities

Hu (Human), Mky (Monkey), Prim (Primate), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Chk (Chicken), Rb (Rabbit), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), EPair for Elisa (EPair), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of Optineurin / HIP7 antibody

OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Altertive splicing results in multiple transcript variants encoding the same protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Optineurin / HIP7 antibody

  Rabbit Polyclonal Optineurin Antibody  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-OPTN rabbit polyclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA590464) Rabbit IgG Purified Can, Hu, Mky, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 (575-591) antibody

  Optineurin Rabbit Polyclonal (aa575-591) Antibody  
Anti-Optineurin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

  Rabbit Polyclonal Anti-OPTN Antibody  
WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Hela cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

  Rabbit Polyclonal Anti-OPTN Antibody  
WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

  Rabbit anti-OPTN Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using OPTN antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

  Rabbit Polyclonal Anti-OPTN Antibody  
Optineurin / HIP7 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 antibody

  Rabbit Polyclonal Anti-OPTN Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (OPTN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Optineurin / HIP7 (115-130) antibody

Adrenal: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Mky, Prim P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

OPTN - human gene knockout kit via CRISPR

OPTN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

OPTN - human gene knockout kit via CRISPR

OPTN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

OPTN - human gene knockout kit via CRISPR

OPTN - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

OPTN - human gene knockout kit via CRISPR

OPTN - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Optn - mouse gene knockout kit via CRISPR

Optn - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Optn - mouse gene knockout kit via CRISPR

Optn - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Optn - mouse gene knockout kit via CRISPR

Optn - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Optn - mouse gene knockout kit via CRISPR

Optn - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Optineurin / HIP7 (transcript variant 1)

  Recombinant protein of human optineurin (OPTN), transcript variant 1  
Optineurin / HIP7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

OPTN overexpression lysate

OPTN overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

OPTN overexpression lysate

OPTN overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

OPTN overexpression lysate

OPTN overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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