ORAI1 antibody

Principal name

ORAI1 antibody

Alternative names for ORAI1 antibody

ORAI-1, CRACM1, TMEM142A, Protein orai-1, Transmembrane protein 142A, Calcium release-activated calcium channel protein 1

SwissProt ID

Q5M848 (Rat), Q5ZL05 (Chick), Q8BWG9 (Mouse), Q96D31 (Human)

Gene ID

84876 (ORAI1), 109305 (Orai1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Ze (Zebrafish), Eq (Equine), Rb (Rabbit), Ye (Yeast)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of ORAI1 antibody

Cytosolic calcium (Ca2+) has long been known to act as a key second messenger in many intracellular pathways including syptic transmission, muscle contraction, hormol secretion, cell growth and proliferation. Intracellular Ca2+ levels are controlled by either the influx of Ca2+ through the calcium-release-activated Ca2+ channels (CRAC), or from intracellular stores which gained much attention. Recently, several key players of the store operated complex have been identified. Orai1 (also known as CRACM1) acts as the store operated Ca2+ channel (SOC) and STIM1, which acts as the endoplasmic reticulum Ca2+ sensor. The formation of functiol channels requires the presence of both Orai1 and STIM1 proteins working as a complex and involves the co-clustering of Orai1 on the plasma membrane with STIM1 on the endoplasmic reticulum. TRPC1, a member of the transient receptor potential family was also suggested to act as a player in the SOC complex. In T-cells, Ca2+ entry following activation by antigen-receptor engagement occurs solely through CRAC channels where Orai1 constitutes the pore forming subunit. Orai1 is a plasma membrane protein with four potential transmembrane domains and intracellular N- and C-terminus. In addition, two mammalian homologs to Orai1 have been identified; Orai2 and Orai3. All three, Orai1 Orai2 and Orai3, are capable of forming store operated channels with different magnitudes.

General readings

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP.
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.
Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.
PMID: 18059270

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ORAI1 antibody

TA305897 (0.03ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI1 (N-term) antibody

Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at 1 ug/ml in the (A) absence or (B) presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI1 (C-term) antibody

Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI1 antibody

Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL. Mouse IgG 3F6H5 Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI1 antibody

Western blot analysis of ORAI1 in human spleen tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL. Mouse IgG 6D11A11 Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI1 antibody

Western blot analysis of Jurkat (lanes 1,2) and HL-60 (lanes 3,4) cell lysates: 1, 3. Anti-Human Orai1 (extracellular) antibody, (1:200).2, 4. Anti-Human Orai1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ORAI1 antibody

Western blot analysis of rat spleen (lanes 1 and4), rat pancreas (lanes 2 and 5) and mouse B-cell lymphoma (WEHI) (lanes 3 and 6) lysates: 1-3. Anti-Orai1 (extracellular) antibody, (1:200). 4-6. Anti-Orai1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ORAI1 antibody

WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Eq, Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

ORAI1 antibody

WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

ORAI1 (C-term) antibody

Immunohistochemical staining of human spleen with Rabbit anti Human ORAI1 antibody Cat.-No AP05736PU-N Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ORAI1 (285-298) antibody

Immunohistochemistry: Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE). Goat Aff - Purified Bear, Bt, Can, Eq, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

ORAI1 Control Peptide

ORAI1
50 µg / €160.00
  Acris Antibodies GmbH

ORAI1 Control Peptide

ORAI1
50 µg / €160.00
  Acris Antibodies GmbH

ORAI1 (Center) antibody

Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with ORAI1 Antibody (Center) Cat.-No AP53115PU-N, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ORAI1 antibody

ORAI1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

ORAI1 antibody

ORAI1 polyclonal antibody ( Cat # PAB11461 ) ( 0.03 µg/ml ) staining of human placenta lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

ORAI1 antibody

Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 polyclonal antibody ( Cat # PAB13248 ) at 10 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

ORAI1 antibody

Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 polyclonal antibody ( Cat # PAB13282 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

ORAI1 antibody

Human HepG2; WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; ORAI1 antibody - N-terminal region (ARP50117_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

ORAI1 antibody

Human HepG2; WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; ORAI1 antibody - middle region (ARP50118_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Por WB
50 µg / €350.00
  AVIVA Systems Biology

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