ORAI3 antibody

Principal name

ORAI3 antibody

Alternative names for ORAI3 antibody

TMEM142C, ORAI-3, Transmembrane Protein 142C

SwissProt ID

Q6AXR8 (Rat), Q6P8G8 (Mouse), Q9BRQ5 (Human)

Gene ID

93129 (ORAI3), 309000 (Orai3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of ORAI3 antibody

In non-excitable cells, Ca2+ sigling plays a most important role in important cellular functions such as migration, proliferation and differentiation. In such cells, Ca2+ enters via either non-selective cation channels such as TRPCs or through highly selective Ca2+ such as Ca2+ release-activated Ca2+ channels (CRAC channels) or store-operated Ca2+ entry channels (SOC channels), and the arachidonic acid-regulated Ca2+ channels (ARC channels). Orai channels are part of the molecular components involved in the Ca2+ entry described above. Three Orai channels have been described in mammalian cells: Orai1-3. These channels make up the pore forming unit of CRAC channels. They are membrane proteins with four transmembrane domains and intracellular N- and C-termini. Orai1 and Orai3 share similar distribution and are expressed in the heart, brain, liver, spleen, lung, intestine, lymphoid organs, skin, and skeletal muscle. Expression of Orai2 is more limited and is found mainly in the brain and lower expression is detected in the lung, spleen and intestine. CRAC channels have been for the most part identified as homotetramers of Orai1 interacting with endoplasmic reticulum located STIM1 that are activated by a depletion of intracellular Ca2+ . Orai3 was shown to emit store-operated Ca2+ entry (SOCE) currents along with STIM1/2 in breast cancer cells which are Estrogen Receptor positive (ER+), whereas Orai1/STIM1 are responsible for these currents in Estrogen Receptor negative (ER) cells. Furthermore, inhibition of Orai3 in these cells elicits cell cycle arrest and ultimately apoptosis (normal cells do not undergo apoptosis). ARC channels are composed of a heteropentameric organization of Orai1/Orai3 (in a 3:2 ratio) which interacts with the small fraction of plasma membrane localized STIM1. These channels are activated by low concentrations of arachidonic acid localized at the inner face of the plasma membrane.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ORAI3 (N-term) antibody

Western blot analysis of ORAI3 in A20 cell lysate with ORAI3 antibody at (A) 1, (B) 2 and (C) 4 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI3 (C-term) antibody

Western blot analysis of ORAI3 in A20 cell lysate with ORAI3 antibody at (A) 2 and (B) 4 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI3 antibody

Western blot analysis of ORAI3 in rat spleen lysate with ORAI3 antibody at 2 ug/mL. Mouse IgG 2H2G9 Aff - Purified Hu, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI3 antibody

Western blot analysis of ORAI3 in rat lung tissue lysate with ORAI3 antibody at 2 ug/mL. Mouse IgG 1B4F1 Aff - Purified Hu, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ORAI3 antibody

Western blot analysis of rat heart (lanes 1 and 3) and mouse heart (lanes 2 and 4) membranes: 1, 2. Anti-Orai3 antibody, (1:200). 3, 4. Anti-Orai3 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ORAI3 antibody

WB Suggested Anti-ORAI3 Antibody; Titration: 1.0 ug/ml; Positive Control: Placenta Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ORAI3 (N-term) antibody

Immunocytochemical staining of A20 cells with Rabbit anti Human ORAI3 (AP05738PU-N) Rabbit IgG Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ORAI3 antibody

Figure 1. Immunohistochemical analysis of Formalin-Fixed Paraffin-Embedded Human Uterus tissue using anti-ORAI3 antibody (AP08777PU-N at 5µg/ml). Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ORAI3 antibody

Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ORAI3 Control Peptide

ORAI3
50 µg / €160.00
  Acris Antibodies GmbH

ORAI3 Control Peptide

ORAI3
50 µg / €160.00
  Acris Antibodies GmbH

ORAI3 antibody

ORAI3 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

ORAI3 (N-term) antibody

Immunocytochemistry of ORAI3 in A-20 cells with ORAI3 polyclonal antibody ( Cat # PAB13264 ) at 10 µg/ml. Rabbit Hu, Ms, Rt ICC/IF, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

ORAI3 (C-term) antibody

Immunocytochemistry of ORAI3 in A-20 cells with ORAI3 polyclonal antibody ( Cat # PAB13269 ) at 5 µg/ml. Rabbit Hu, Ms ICC/IF, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

ORAI3 antibody

Immunohistochemistry-Paraffin: ORAI3 Antibody [NBP1-93523] Immunohistochemical staining of human testis shows strong nuclear and cytoplasmic positivity in cells of seminiferus ducts. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

15 Item(s)

per page
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