ORC1 / PARC1 antibody

Principal name

ORC1 / PARC1 antibody

Alternative names for ORC1 / PARC1 antibody

ORC1L, Replication control protein 1, Origin recognition complex subunit 1

SwissProt ID

Q13415 (Human), Q58DC8 (Bovin), Q80Z32 (Rat), Q9JI69 (Crigr), Q9Z1N2 (Mouse)

Gene ID

4998 (ORC1)

Available reactivities

Hu (Human), Hst (Hamster), Xen (Xenopus), Ye (Yeast), Rt (Rat), Ms (Mouse)

Available hosts

Mouse, Goat, Rat, Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), PLA/Proximity ligation assay (PLA), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ORC1 / PARC1 antibody

ORC, the origin recognition complex, is a multi-subunit protein complex that is composed of 6 different proteins ranging in molecular weight from 50 to 120 kDa. The complex was originally identified in S. cerevisiae and is essential for the initiation of DNA replication. The proteins bind to a specific recognition sequence in the origin region and remain bound to the DNA throughout the cell cycle. The second largest of the proteins, the 71 kDa Orc2p, is encoded by ORC2. ORC2, also called RRR1 or SIR5, is an essential gene in S. cerevisiae and is required for both replication and transcriptional silencing. ORC is present at little more than one complete complex per replication origin and binds at origins immediately after initiation in the previous cell cycle. Assembly of additional complexes occurs in multiple stages during the cell cycle and includes a pre-replicative complex (pre-RC) as well as other proteins. Orc2p, along with Orc5p, forms a complex with Cdc6p, a protein required for initiation of DNA replication. Since ORC and Cdc6p bind as a complex at individual DNA replication origins, ORC and Cdc6p may cooperate to determine the frequency of initiation of replication and also repress transcription of specific genes. Although the origin of DNA replication has been difficult to demonstrate in other eukaryotic species, the ORC function has been conserved through eukaryotes with orthologs of ORC2 having been identified in other eukaryotes including humans, mice, C. elegans, Drosophila, Xenopus, and various yeast and plant species.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ORC1 / PARC1 antibody

Western blot analysis of extracts from HepG2 cells, using ORC1L antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ORC1 / PARC1 antibody

ORC1 / PARC1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ORC1 / PARC1 antibody

Immunoperoxidase of monoclonal antibody to ORC1L on formalin-fixed paraffin-embedded human uterine cervix. [antibody concentration 3 ug/ml] Mouse IgG2b 3H1 Purified Hu E, P
0.1 mg / €370.00
  Abnova Taiwan Corp.

ORC1 / PARC1 antibody

ORC1 / PARC1 Rat IgG1 7A7 Hu IP, WB
50 µl / €470.00
  Abnova Taiwan Corp.

ORC1 / PARC1 antibody

Western blot analysis of ORC1 expression in HeLa (A); MCF7 (B); PC12 (C); Ramos (D) whole cell lysates. Rabbit Aff - Purified Hu, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

ORC1 / PARC1 antibody

Western blot analysis of ORC1 expression in HeLa (A); MCF7 (B); PC12 (C); Ramos (D) whole cell lysates. Rabbit Aff - Purified Hu, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

ORC1 / PARC1 antibody

Western blot analysis of ORC1 expression in HeLa (A); MCF7 (B); PC12 (C); Ramos (D) whole cell lysates. Rabbit Aff - Purified Hu, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

ORC1 / PARC1 antibody

ORC1 Antibody [7A7] Rat IgG1 7A7 Purified Hu IP, WB
50 µl / €360.00
  Immuquest

ORC1 / PARC1 antibody

ORC1 / PARC1 Mouse IgG1 7F6/1 Purified Hu WB
0.1 mg / €320.00
  Novus Biologicals Inc.

ORC1 / PARC1 antibody

Western Blot: ORC1 Antibody [NBP1-05956]-Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells.Affinity purified rabbit anti-ORC1 antibody used for IP at 3 mcg/mg lysate. ORC1 was also immunoprecipitated by rabbit anti-ORC1 antibody NBP1-05957, which recognizes a downstream epitope Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

ORC1 / PARC1 antibody

Western Blot and Immunoprecipitation: ORC1 Antibody [NBP1-05957] - Whole cell lysate from HeLa cells. ORC1 was also immunoprecipitated by rabbit anti-ORC1 antibody NBP1-05956. Rabbit IgG Aff - Purified Hu IP, PLA, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

ORC1 / PARC1 antibody

Immunohistochemistry-Paraffin: ORC1 Antibody [NBP1-83184] - Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells and glial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ORC1 / PARC1

ORC1 / PARC1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ORC1 / PARC1

ORC1 / PARC1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ORC1L 293T Cell Transient Overexpression Lysate(Denatured)

ORC1L 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

ORC1 overexpression lysate

ORC1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

16 Item(s)

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