Orexin antibody

Principal name

Orexin antibody

Alternative names for Orexin antibody

HCRT, OX, PPORX, PPOX, Hypocretin

SwissProt ID

O43612 (Human), O55232 (Rat), O55241 (Mouse), O77668 (Pig), P56717 (Bovin), Q9GLF6 (Canfa)

Gene ID

3060 (HCRT), 25723 (Hcrt)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), Rhesus Mky (Rhesus Monkey), GP (Guinea Pig), Sh (Sheep)

Available hosts

Sheep, Rabbit, Mouse, Chicken

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of Orexin antibody

The hypothalamus acts as a major regulatory center involved in the control of feeding behavior and energy homeostasis. Several neuropeptides and proteins have been shown to be involved in the regulation of these processes. Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B(hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro-orexin, which is encoded by a gene localized to human chromosome 17q21. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behavior. Prepro-orexin mRNA expression is upregulated upon fasting. Immunocytochemical mapping of Orexin A has identified a population of medium sized neurons within the hypothalamus, median eminence and ventral thalamic nuclei of the rat brain. This distribution has been confirmed in the human brain. Orexin-containing neurons diffusely innervate the entire brain, including monosynaptic projections to various regions of the cerebral cortex, limbic system, and brain stem. Orexin A and orexin B bind to and activate two closely related G protein-coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. OX1 receptor is selective for orexin A, whereas OX2 receptor is a nonselective receptor for both orexin A and orexin B. OX1 and OX2 mRNA are found in additional brain areas outside the hypothalamus, suggesting that orexin A and B may play additional regulatory roles in the central nervous system, such as arousal, locomotor activity and neuroendocrine functions. Dysfunction of the orexin peptide system has been linked to narcolepsy. Orexin knockout mice exhibit a phenotype strikingly similar to human narcolepsy patients, as well as to canarc 1 mutant dogs, which carry a deletion in the OX2 receptor/Hcrtr2.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Orexin antibody

Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using HCRT antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin antibody

Host: Rabbit; Target Name: Hcrt; Sample Tissue: Rat Testis lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Orexin (2-14) antibody

Formalin-Fixed Paraffin-Embedded Human Brain hypothalamus stained with Orexin Antibody Cat.-No AP07538PU-N at 10 µg/ml Sheep Ig Fraction Bov, Can, Eq, Hu, Por, Rb, Rhesus Mky, Rt C, P
50 µg / €470.00
  Acris Antibodies GmbH

Orexin antibody

Orexin Sheep Hu E, P
50 µl / €480.00
  Novus Biologicals Inc.

Orexin-A Control Peptide

Orexin-A WB
0.25 mg / €250.00
  Acris Antibodies GmbH

Orexin-A antibody

Orexin-A Rabbit Aff - Purified Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Orexin-A (2-14) antibody

Staining of paraffin embedded human hypothalamus with sheep anti human Orexin A. Sheep Purified Hu C, E, P
1 ml / €360.00
  Acris Antibodies GmbH

Orexin-A antibody

Staining of paraffin embedded human hypothalamus with sheep anti human Orexin A. Sheep IgG Hu C, E, P
0.5 ml / €340.00
  Novus Biologicals Inc.

Orexin-B antibody

 Orexin B and p38 alpha  were detected in frozen sections of mouse brainstem using mouse anti-human Orexin B monoclonal antibody (red) and rabbit anti-human/mouse/rat p38 alpha affinity-purified polyclonal antibody (green). Mouse IgG1 145202 Purified Hu C
0.5 mg / €410.00
  Neuromics Antibodies

Lysates

Catalog No.    

HCRT overexpression lysate

HCRT overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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