Orexin antibody

Principal name

Orexin antibody

Alternative names for Orexin antibody

HCRT, OX, PPORX, PPOX, Hypocretin

SwissProt ID

O43612 (Human), O55232 (Rat), O55241 (Mouse), O77668 (Pig), P56717 (Bovin), Q9GLF6 (Canfa)

Gene ID

3060 (HCRT), 25723 (Hcrt), 15171

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), Rhesus Mky (Rhesus Monkey), Rt (Rat), Ms (Mouse), GP (Guinea Pig), Sh (Sheep)

Available hosts

Sheep, Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of Orexin antibody

Orexin-A is a hypothalamic neuropeptide that belongs to the Orexin family (Orexin-A and Orexin-B) (1). Orexin neuropeptides -A and -B or Orexins are also known as Hypocretins. Orexin-A and –B are derived from the same precursor peptide (prepro-orexin) by proteolytic processing whose gene is located at human chromosome 17q21 (2). Orexins are produced by a small group of neurons located in the later hypothalamic and perifornical areas, with widespread projections to the entire neuroaxis (3). Orexinergic neurons of the lateral hypothalamus act as glucose sensors. Orexin signals hunger when blood glucose levels are low. Orexins also play a significant role in the regulation of sleep-wakefulness and body fluids and, in homeostatic regulation of energy metabolism, autonomic function and hormonal balance (4). Orexins mediate their effects by binding to two G-Protein-Coupled Receptors (OXR1 and OXR2). Orexin-A binds to both OXR1 and OXR2 with high affinity (5).
Orexin binding to its associated receptor activates the hypoxia-inducible factor 1 (HIF-1) transcription factor in the hypothalamus which results in increased glucose uptake and higher glycolytic activity. Mice lacking orexins or their cognate receptors eat less compared with matched littermates that do not lack them and, display a sleep disorder that is similar to human narcolepsy (6). Therefore, orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid of most narcoleptic patients. Orexin-A is expressed in subthalamic nucleus, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle. It is approximately a 16kDa protein (131 amino acids).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Orexin antibody

Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using HCRT antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin antibody

Host: Rabbit; Target Name: Hcrt; Sample Tissue: Rat Testis lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Orexin antibody

Gel: 12%SDS-PAGE,Lysate: 40 ug,,Primary antibody: (HCRT Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin (2-14) antibody

Formalin-Fixed Paraffin-Embedded Human Brain hypothalamus stained with Orexin Antibody Cat.-No AP07538PU-N at 10 µg/ml Sheep Ig Fraction Bov, Can, Eq, Hu, Por, Rb, Rhesus Mky, Rt C, P
50 µg / €470.00
  Acris Antibodies GmbH

Orexin-A Control Peptide

Orexin-A WB
0.25 mg / €250.00
  Acris Antibodies GmbH

Orexin-A antibody

Orexin-A Rabbit Aff - Purified Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Orexin-A (2-14) antibody

Staining of paraffin embedded human hypothalamus with sheep anti human Orexin A. Sheep Purified Hu C, E, P
1 ml / €360.00
  Acris Antibodies GmbH

Orexin-B antibody

 Orexin B and p38 alpha  were detected in frozen sections of mouse brainstem using mouse anti-human Orexin B monoclonal antibody (red) and rabbit anti-human/mouse/rat p38 alpha affinity-purified polyclonal antibody (green). Mouse IgG1 145202 Purified Hu C
0.5 mg / €410.00
  Neuromics Antibodies

Lysates

Catalog No.    

HCRT overexpression lysate

HCRT overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hcrt (GFP-tagged ORF) - Rat hypocretin (Hcrt), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hcrt (GFP-tagged ORF) - Rat hypocretin (Hcrt), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Hcrt (Myc-DDK-tagged ORF) - Rat hypocretin (Hcrt), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hcrt (Myc-DDK-tagged ORF) - Rat hypocretin (Hcrt), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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