Orexin receptor type 1 antibody

Principal name

Orexin receptor type 1 antibody

Alternative names for Orexin receptor type 1 antibody

Hypocretin receptor type 1, HCRTR1, Ox1r

SwissProt ID

O43613 (Human), O97661 (Pig), P56718 (Rat), P58307 (Mouse), Q0GBZ5 (Bovin)

Gene ID

3061 (HCRTR1), 3060 (HCRT), 282248, 25593 (Hcrtr1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Sh (Sheep), Bov (Bovine), Rb (Rabbit), Por (Porcine), Bt (Bat), Eq (Equine), Mky (Monkey), Gorilla, GP (Guinea Pig)

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of Orexin receptor type 1 antibody

Orexin Receptor 1 (OX1R) (also known as hypocretin receptor 1) is one of two receptors that recognize the peptide neurotransmitters orexin A and orexin B.Orexin A and B are 33 and 28 amino acids in length, respectively, and are derived from a common precursor termed prepro-orexin. OX1R binds orexin A with greater affinity than orexin B (a one order of magnitude difference), while OX2R binds both ligands with similar affinities.Both OX1R and OX2R belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. OX1R is thought to transmit sigls through the Ga11 class of G proteins, resulting in the activation of phospholipase C with subsequent triggering of the phosphatidylinositol cascade and an influx of extracellular Ca2+, probably through transient receptor potential (TRP) channels.The physiological functions of the orexin system (OX1R, OX2R, and their ligands) have been a matter of intense research in the last few years. OX1R is expressed in both the central nervous system and peripheral locations such as gastrointestil tissues, pancreas, and testis.It appears to be involved in the regulation of feeding behavior in rodents since an OX1R antagonist is able to inhibit baseline feeding.The orexin system has been shown to be involved in the regulation of sleep and wakefulness states and OX1R knockout mice show defects in the regulation of rapid eye movement (REM) sleep, among other phenotypic alterations.In addition, the orexin system is involved in regulating autonomic functions such as blood pressure and heart rate, as well as in mechanisms that regulate the reward response in the brain.

General readings

Peltonen, H.M., et al. Biochim. Biophys. Acta 1803(10):1206-1212(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010)
Turunen, P.M., et al. Br. J. Pharmacol. 159(1):212-221(2010)
El Firar, A., et al. FASEB J. 23(12):4069-4080(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Orexin Receptor 1+2 (C-term) antibody

Immunohistochemistry with Orexin Receptor polyclonal antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Orexin receptor type 1 antibody

Western blot analysis of mouse brain lysate: 1. Anti-Orexin Receptor 1 antibody , (1:200). 2. Anti-Orexin Receptor 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Orexin receptor type 1 antibody

AP31067PU-N HCRTR1 antibody staining of Human Brain lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt, Sh E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Orexin receptor type 1 antibody

Western blot analysis of extracts from RAW264.7 cells, using HCRTR1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin receptor type 1 antibody

Anti-HCRTR1 / Orexin Receptor 1 antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

Orexin receptor type 1 antibody

Anti-HCRTR1 / Orexin Receptor 1 antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €345.00
  OriGene Technologies, Inc.

Orexin receptor type 1 antibody

Anti-HCRTR1 / Orexin Receptor 1 antibody IHC of human brain, anterior pituitary cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

Orexin receptor type 1 antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and liver cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using HCRTR1 antibody at dilution 1/70, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin receptor type 1 antibody

Predicted cell location: Cytoplasm. Positive control: Human renal and lung cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human renal cancer tissue using HCRTR1 antibody at dilution 1/100, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin receptor type 1 antibody

WB Suggested Anti-HCRTR1 Antibody; Titration: 0.25 ug/ml; Positive Control: Fetal Brain Rabbit IgG Purified Bov, Can, GP, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Orexin receptor type 1 (Center) antibody

Western blot analysis of Orexin receptor type 1 Antibody (Center) Cat.-No AP52020PU-N in NCI-H292 cell line lysates (35ug/lane). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Orexin receptor type 1 antibody

Orexin receptor type 1 Rabbit Hu, Ms, Rb, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Orexin receptor type 1 antibody

Immunohistochemical staining of HCRTR1 in rat zona incerta neurons using HCRTR1 polyclonal antibody ( Cat # PAB14322 ), at a dilution of 1 : 1000. Rabbit Bov, Rt C
0.1 ml / €390.00
  Abnova Taiwan Corp.

Orexin receptor type 1 antibody

Immunofluorescence analysis of MCF7 cells, using HCRTR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €205.00
  Assay Biotech

Orexin receptor type 1 antibody

Immunofluorescence analysis of MCF7 cells, using HCRTR1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

Orexin receptor type 1 antibody

Western blot analysis of extracts from RAW264.7 cells, using HCRTR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

Orexin receptor type 1 antibody

Western blot analysis of extracts from RAW264.7 cells, using HCRTR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Orexin receptor type 1 antibody

Orexin receptor type 1 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Orexin receptor type 1 antibody

NB100-93465 (0.5ug/ml) staining of Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Orexin receptor type 1 antibody

Orexin receptor type 1 Rabbit Purified Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

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