Orexin receptor type 2 antibody

Principal name

Orexin receptor type 2 antibody

Alternative names for Orexin receptor type 2 antibody

HCRTR2, Ox2r, Hypocretin receptor type 2

SwissProt ID

O43614 (Human), O62809 (Pig), P56719 (Rat), P58308 (Mouse), Q9TUP7 (Canfa)

Gene ID

3062 (HCRTR2), 25605 (Hcrtr2), 387285

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C), Paraffin Sections (P)

Background of Orexin receptor type 2 antibody

Orexin Receptor 2 (OX2R) (also known as hypocretin receptor 2) is one of two receptors that recognize the peptide neurotransmitters orexin A and orexin B.Orexin A and B are 33 and 28 amino acids in length, respectively, and are derived from a common precursor termed prepro-orexin.OX2R binds both orexin A and B with similar affinities while OX1R binds orexin A with greater affinity than orexin B (a one order of magnitude difference).Both OX2R and OX1R belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. OX2R is thought to transmit sigls through the Ga11 class of G proteins, resulting in the activation of phospholipase C with subsequent triggering of the phosphatidylinositol cascade and an influx of extracellular Ca2+, probably through transient receptor potential (TRP) channels. OX2R can also transmit sigls through inhibitory Gi G proteins, although the mechanism is less well understood.The physiological functions of the orexin system (OX1R, OX2R, and their ligands) have been a matter of intense research over the last few years. OX2R is expressed in both the central nervous system and peripheral locations such as gastrointestil tissues, pancreas, and testis.The best studied physiological role of OX2R is its involvement in the regulation of sleep and wakefulness states. Studies in mice lacking the orexin gene and dogs expressing a mutation of the OX2R show a remarkably similar phenotype to human rcolepsy, a condition characterized by excessive daytime sleepiness, ibility to maintain vigilant states, and defects in the regulation of rapid eye movement (REM) sleep.In addition, the orexin system is involved in regulating autonomic functions such as blood pressure and heart rate, as well as in mechanisms that regulate the reward response in the brain.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010)
Chen, J., et al. Biochem. J. 427(3):377-390(2010)
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Orexin receptor type 2 antibody

  Rabbit polyclonal Anti-Orexin Receptor 2  
Western blot analysis of human Colo-205 (lanes 1 and 3) and HT-29 (lanes 2 and 4) colon cancer cell lysates: 1, 2. Anti-Orexin Receptor 2 antibody , (1:200). 3, 4. Anti-Orexin Receptor 2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Orexin receptor type 2 antibody

  Goat Polyclonal Antibody against HCRTR2  
TA303293 (1µg/ml) staining of human brain (hippocampus) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Orexin receptor type 2 (390-402) antibody

  OX2R / Orexin Receptor 2 Goat Polyclonal (aa390-402) Antibody  
Anti-HCRTR2 / Orexin Receptor 2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. Goat IgG Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

Orexin receptor type 2 antibody

  Anti-HCRTR2 Rabbit Polyclonal Antibody  
Predicted band size: 51 kDa . Positive control: Mouse kidney, brain and heart tissue lysate. Recommended dilution: 1/1000-5000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin receptor type 2 antibody

  Anti-HCRTR2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human lung and ovarian cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using HCRTR2 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Orexin receptor type 2 (Center) antibody

Western blot analysis of Orexin receptor type 2 Antibody (Center) Cat.-No AP52021PU-N in mouse kidney tissue lysates (35ug/lane). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Orexin receptor type 2 antibody

Orexin receptor type 2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

HCRTR2 - human gene knockout kit via CRISPR

HCRTR2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

HCRTR2 - human gene knockout kit via CRISPR

HCRTR2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

HCRTR2 - human gene knockout kit via CRISPR

HCRTR2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

HCRTR2 - human gene knockout kit via CRISPR

HCRTR2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hcrtr2 - mouse gene knockout kit via CRISPR

Hcrtr2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Hcrtr2 - mouse gene knockout kit via CRISPR

Hcrtr2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hcrtr2 - mouse gene knockout kit via CRISPR

Hcrtr2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Hcrtr2 - mouse gene knockout kit via CRISPR

Hcrtr2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, HCRTR2 (mGFP-tagged) - Human hypocretin (orexin) receptor 2 (HCRTR2), 200 uL, >10^7 TU/mL

Lenti ORF particles, HCRTR2 (mGFP-tagged) - Human hypocretin (orexin) receptor 2 (HCRTR2), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, HCRTR2 (Myc-DDK tagged) - Human hypocretin (orexin) receptor 2 (HCRTR2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, HCRTR2 (Myc-DDK tagged) - Human hypocretin (orexin) receptor 2 (HCRTR2) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hcrtr2 (GFP-tagged) - Mouse hypocretin (orexin) receptor 2 (Hcrtr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hcrtr2 (GFP-tagged) - Mouse hypocretin (orexin) receptor 2 (Hcrtr2), 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

Lenti ORF particles, Hcrtr2 (Myc-DDK-tagged) - Mouse hypocretin (orexin) receptor 2 (Hcrtr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hcrtr2 (Myc-DDK-tagged) - Mouse hypocretin (orexin) receptor 2 (Hcrtr2), 200 uL, >10^7 TU/mL  
200 µl / €950.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Hcrtr2 (GFP-tagged ORF) - Rat hypocretin (orexin) receptor 2 (Hcrtr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Hcrtr2 (GFP-tagged ORF) - Rat hypocretin (orexin) receptor 2 (Hcrtr2), 200 uL, >10^7 TU/mL  
200 µl / €1,070.00
  OriGene Technologies, Inc.

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