OSBP2 antibody

Principal name

OSBP2 antibody

Alternative names for OSBP2 antibody

Oxysterol-binding protein 2, KIAA1664, ORP4, OSBPL4, OSBP-related protein 4, Oxysterol-binding protein-related protein 4

SwissProt ID

Q5QNQ6 (Mouse), Q969R2 (Human)

Gene ID

23762 (OSBP2), 2623762 (flgI)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of OSBP2 antibody

The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

OSBP2 antibody

OSBP2 Mouse IgG2a 2B4 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

OSBP2 antibody

OSBP2 Goat Hu, Ms E
0.1 mg / €390.00
  Abnova Taiwan Corp.

OSBP2 antibody

Immunohistochemistry-Paraffin: OSBP2 Antibody [NBP1-81388] - Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

OSBP2 (transcript variant 1)

OSBP2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

OSBP2

OSBP2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

OSBP2

OSBP2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

OSBP2 overexpression lysate

OSBP2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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