OSMR antibody

Principal name

OSMR antibody

Alternative names for OSMR antibody

Oncostatin-M receptor beta, OSMRB, IL-31 receptor beta, IL-31R-beta, IL-31RB, Oncostatin-M specific receptor subunit beta, Interleukin-31 receptor subunit beta

SwissProt ID

O70458 (Mouse), Q65Z14 (Rat), Q99650 (Human)

Gene ID

9180 (OSMR), 18414 (Osmr), 310132

Available reactivities

Hu (Human), Can (Canine), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of OSMR antibody

Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Arita,K., (2008) Am. J. Hum. Genet. 82 (1), 73-80

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