Osteocalcin antibody

Principal name

Osteocalcin antibody

Alternative names for Osteocalcin antibody

Bone Gla protein, BGLAP, Gamma-carboxyglutamic acid-containing protein

SwissProt ID

P02818 (Human), P02820 (Bovin), P02821 (Felca), P02822 (Chick), P04640 (Rat), P04641 (Mouse), P40147 (Xenla), Q8HYY9 (Pig)

Gene ID

632 (BGLAP), 12096 (Bglap), 281646, 12097 (Bglap2)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Gt (Goat), Hu (Human), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Elk, Mky (Monkey), Ms (Mouse)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), ELISA (capture) (E(capture)), ELISA (detection) (E(detection))

Background of Osteocalcin antibody

Osteocalcin belongs to the osteocalcin/matrix Gla protein family and constitutes 1 to 2% of the total bone protein. It is a 49 amino acid single chain vitamin K dependent protein, made by osteoblasts, and is a major component of the noncollagenous bone matrix. Post translational modification by a vitamin K dependent carboxylase produces three gamma carboxyglutamic acid residues at positions 17, 21 and 24, giving it a high affinity for calcium. It also binds strongly to apatite. Sixty to ninety percent of de novo synthesized osteocalcin is incorporated into the bone matrix where it binds to hydroxyapatite during matrix mineralization. The remainder of the osteocalcin is released into the circulation where it can be measured as a sensitive marker of bone formation. Osteocalcin found in serum is almost exclusively derived from the bone formation with little or no contribution from the resorption process. Drugs acting primarily on bone resorption, such as bisphosphonates, induce a rapid decline in specific bone resorption markers, whereas osteocalcin levels only change after extended therapy periods, in accordance with the expected dynamics of a bone formation marker. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Osteocalcin antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and ovarian cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using BGLAP antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Osteocalcin antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian and lung cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using BGLAP antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Osteocalcin antibody

Osteocalcin Mouse IgG1 3G8E1F11 Purified Bov, Hu E
0.2 mg / €330.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Mouse IgG2a 2H9F11F8 Purified Bov, Hu, Por, Rb, Rt E
0.2 mg / €320.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Mouse IgG1 6F9G4E10 Purified Hu E
0.2 mg / €330.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Mouse IgG1 8H12F9H10 Purified Bov, Hu, Por, Rb, Rt E
0.2 mg / €340.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Mouse IgG2a 3H8H12D2A12F12 Purified Bov, Hu, Por, Rb, Rt E
0.2 mg / €320.00
  Acris Antibodies GmbH

Osteocalcin (1-22) antibody

Osteocalcin Rabbit Serum Hu E, R
0.1 ml / €380.00
  Acris Antibodies GmbH

Osteocalcin (1-22) antibody

Osteocalcin Rabbit Serum Hu E, R
20 µl / €150.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Rabbit IgG Purified Hu E, WB
1 ml / €390.00
  Acris Antibodies GmbH

Osteocalcin (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

Osteocalcin (C-term)/(C-term C80) antibody

BGLAP Antibody (C80) (Cat. #AP50371PU-N) western blot analysis in HepG2 cell line lysates (35µg/lane).This demonstrates the BGLAP antibody detected the BGLAP protein (arrow). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Rabbit Serum Bov, Can, Elk, Hu, Mky C
0.25 ml / €480.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Rabbit Serum Bov, Can, Hu, Mky C, F
0.25 ml / €650.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Goat Serum Ms C, ICC/IF
0.1 ml / €330.00
  Acris Antibodies GmbH

Osteocalcin antibody

Osteocalcin Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Osteocalcin antibody

Western Blot analysis of BGLAP expression in transfected 293T cell line (H00008682-T01) by BGLAP MaxPab polyclonal antibody.

Lane 1: BGLAP transfected lysate(11.00 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Osteocalcin antibody

Osteocalcin Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Osteocalcin antibody

Immunofluorescence of monoclonal antibody to BGLAP on HeLa cell . [antibody concentration 10 ug/ml] Mouse IgG1 2D4 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Osteocalcin antibody

Osteocalcin Mouse IgG1 2D5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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