Osteoprotegerin / TNFRSF11B antibody

Principal name

Osteoprotegerin / TNFRSF11B antibody

Alternative names for Osteoprotegerin / TNFRSF11B antibody

OPG, OCIF, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor

SwissProt ID

O00300 (Human), O08712 (Mouse)

Gene ID

4982 (TNFRSF11B), 18383 (Tnfrsf11b)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of Osteoprotegerin / TNFRSF11B antibody

Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.

General readings

Min H., et al. (2000) J Exp Med. 192:463-474.Simonet WS., et al. (1997) Cell. 89:309-319.

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Osteoprotegerin / TNFRSF11B antibody

  Rabbit polyclonal anti-TR11B antibody  
Western blot analysis of extracts from 293 cells, using TR11B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

  Anti-TNFRSF11B Rabbit Polyclonal Antibody  
Predicted band size: 46 kDa . Positive control: Mouse kidney tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

  Anti-TNFRSF11B Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human brain and liver cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human brain and liver cancer tissue using TNFRSF11B antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

  TNFRSF11B Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using TNFRSF11B antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €335.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

Immunohistochemistry analysis of OPG antibody (Cat.-No AP06631PU-N) in paraffin-embedded human liver carcinoma tissue Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

Osteoprotegerin / TNFRSF11B antibody

Western blot analysis of extracts from 293 cells, using TR11B Antibody . The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

Osteoprotegerin / TNFRSF11B antibody

Western blot analysis of extracts from 293 cells, using TR11B Antibody . The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

ELISA Kits

Catalog No.    

Mouse OPG ELISA Kit

Mouse OPG ELISA Kit  
1 kit / €484.00
  OriGene Technologies, Inc.

8 Item(s)

per page
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