Osteoprotegerin / TNFRSF11B antibody

Principal name

Osteoprotegerin / TNFRSF11B antibody

Alternative names for Osteoprotegerin / TNFRSF11B antibody

OPG, OCIF, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor

SwissProt ID

O00300 (Human), O08712 (Mouse)

Gene ID

4982 (TNFRSF11B), 18383 (Tnfrsf11b)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of Osteoprotegerin / TNFRSF11B antibody

Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.

General readings

Min H., et al. (2000) J Exp Med. 192:463-474.Simonet WS., et al. (1997) Cell. 89:309-319.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Osteoprotegerin / TNFRSF11B antibody

  Mouse Monoclonal Osteoprotegerin/TNFRSF11B Antibody (98A1071)  
Western Blot: Osteoprotegerin Antibody (98A1071) [TA336370] - analysis of Daudi lysate using the OPG antibody at 1 ug/ml. Mouse IgG1 98A1071 Purified Hu C, ICC/IF, IP, P, WB
0.1 mg / €416.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

  Anti-TNFRSF11B Rabbit Polyclonal Antibody  
Predicted band size: 46 kDa . Positive control: Mouse kidney tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

  Anti-TNFRSF11B Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human brain and liver cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human brain and liver cancer tissue using TNFRSF11B antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

  Anti-Human OPG Rabbit Polyclonal Antibody  
To detect hOPG by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human OPG (TA328411) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hOPG. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €335.00
  OriGene Technologies, Inc.

Osteoprotegerin / TNFRSF11B antibody

Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and lung cancer tissues (right) using TNFRSF11B antibody Cat.-No AM06550SU-N with DAB staining. Mouse IgG1 5A11 Ascites Hu E, P, WB
0.1 ml / €400.00
  OriGene Technologies GmbH

Osteoprotegerin / TNFRSF11B antibody

Immunohistochemistry analysis of OPG antibody (Cat.-No AP06631PU-N) in paraffin-embedded human liver carcinoma tissue Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

Osteoprotegerin / TNFRSF11B antibody

Human Pancreas, Exocrine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µl / €380.00
  OriGene Technologies GmbH

Osteoprotegerin / TNFRSF11B antibody

Formalin-fixed, paraffin-embedded sections of human breast invasive ductal carcinoma stained with Osteoprotegerin Antibody Cat.-No PP1107P. Tissue samples were provided by the Cooperative Human Tissue Network which is funded by the National Cancer Institute. Rabbit Aff - Purified Hu E, P, WB
50 µg / €230.00
  OriGene Technologies GmbH

Osteoprotegerin / TNFRSF11B antibody

Formalin-fixed, paraffin-embedded sections of human breast invasive ductal carcinoma stained with Osteoprotegerin Antibody Cat.-No PP1107P. Tissue samples were provided by the Cooperative Human Tissue Network which is funded by the National Cancer Institute. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

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