Osteoprotegerin / TNFRSF11B antibody

Principal name

Osteoprotegerin / TNFRSF11B antibody

Alternative names for Osteoprotegerin / TNFRSF11B antibody

OPG, OCIF, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor

SwissProt ID

O00300 (Human), O08712 (Mouse)

Gene ID

4982 (TNFRSF11B), 18383 (Tnfrsf11b)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of Osteoprotegerin / TNFRSF11B antibody

Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.

General readings

Min H., et al. (2000) J Exp Med. 192:463-474.Simonet WS., et al. (1997) Cell. 89:309-319.

4 Item(s)

per page

CRISPR

Catalog No. Species Donor Vector  

Tnfrsf11b - mouse gene knockout kit via CRISPR

Tnfrsf11b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf11b - mouse gene knockout kit via CRISPR

Tnfrsf11b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf11b - mouse gene knockout kit via CRISPR

Tnfrsf11b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf11b - mouse gene knockout kit via CRISPR

Tnfrsf11b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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