OTUD5 antibody

Principal name

OTUD5 antibody

Alternative names for OTUD5 antibody

Deubiquitinating enzyme A, DUBA, OTU domain-containing protein 5

SwissProt ID

Q2YDU3 (Rat), Q3U2S4 (Mouse), Q96G74 (Human)

Gene ID

55593 (OTUD5), 5559329 (A7X013)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)

Background of OTUD5 antibody

OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

OTUD5 (C-term) antibody

Western blot analysis of OTUD5 in human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

OTUD5 control peptide

OTUD5
50 µg / €160.00
  Acris Antibodies GmbH

OTUD5 antibody

OTUD5 Goat Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

OTUD5 antibody

Western Blot: OTUD5 Antibody [NBP1-49936] - Detection of Human and Mouse DUBA by Western Blot (h&m) and Immunoprecipitation (h).  Samples:  Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg) and mouse NIH3T3 (M; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-DUBA antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.  DUBA was also immunoprecipitated by rabbit anti-DUBA antibody which recognizes a downstream epitope.  For blotting immunoprecipitated DUBA was used.   Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Rabbit Aff - Purified Hu, Ms IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

OTUD5 antibody

Western Blot: OTUD5 Antibody [NBP1-49937] - Detection of Human and Mouse DUBA by Western Blot (h&m) and Immunoprecipitation (h).  Samples:  Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg) and mouse NIH3T3 (M; 50 mcg) cells.  Antibodies: Affinity purified rabbit anti-DUBA antibody  used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.  DUBA was also immunoprecipitated by rabbit anti-DUBA antibody which recognizes a downstream epitope.  For blotting immunoprecipitated DUBA was used.   Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). Rabbit Aff - Purified Hu, Ms IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

OTUD5 antibody

Immunohistochemistry-Paraffin: OTUD5 Antibody [NBP1-76943] - Mouse kidney tissue with OTUD5 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

OTUD5 (transcript variant 1)

OTUD5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

OTUD5

OTUD5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

OTUD5

OTUD5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

OTUD5 overexpression lysate

OTUD5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

OTUD5 overexpression lysate

OTUD5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

OTUD5 overexpression lysate

OTUD5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

per page
  • LinkedIn