P2RX3 / P2X3 antibody

Principal name

P2RX3 / P2X3 antibody

Alternative names for P2RX3 / P2X3 antibody

P2X purinoceptor 3, ATP receptor, Purinergic receptor

SwissProt ID

P49654 (Rat), P56373 (Human), Q3UR32 (Mouse)

Gene ID

81739 (P2rx3), 5024 (P2RX3)

Available reactivities

Rt (Rat), Hu (Human), Mky (Monkey), Ms (Mouse), Prim (Primate), Rb (Rabbit), Gorilla

Available hosts

Guinea Pig, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of P2RX3 / P2X3 antibody

Purinergic receptor P2X, ligand-gated ion channel, 3, also known as P2X3, is a human gene. Its gene is mapped to 11q12. P2X purinoceptors are 397 to 492 amino acids long and have a predicted structure of 2 short intracellular domains, 2 transmembrane-spanning regions, and a large extracellular domain. The P2X3 subunit has 43% and 47% identity with P2X1 and P2X2, respectively; 10 cysteine residues are conserved in all 3 subtypes, so that tertiary structures may also be conserved. P2X3 was the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel, coupled with a sensory neuron-like pharmacology, suggested that it may transduce ATP-evoked nociceptor activation. If ATP, and more specifically, P2X3 purinoceptors are involved in nociception, then the development of an antagonist selective for P2X3 could prove useful in pain relief. Lack of P2X3 in other tissues than sensory ganglia could afford a degree of specificity, leading to fewer side effects.

General readings

General / background references:Vulchanova L et al. P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci 10:3470-8 (1998). PubMed PMID: 9824460
Vulchanova L et al. Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 36:1229-42 (1997). PubMed PMID: 9364478

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

P2RX3 / P2X3 antibody

Anti-P2RX3 / P2X3 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu, Mky, Rb
50 µg / €345.00
  OriGene Technologies, Inc.

P2RX3 / P2X3 antibody

Western blot analysis of rat DRG lysates: 1. Anti-P2X3 Receptor antibody (APR-016), (1:200). 2. Anti-P2X3 Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

P2RX3 / P2X3 antibody

Western blot analysis of rat DRG: 1. Anti-P2X3 Receptor (extracellular) antibody , (1:200). 2. Anti-P2X3 Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

P2RX3 / P2X3 antibody

P2RX3 / P2X3 Guinea Pig Serum Rt C, ICC/IF, WB
0.1 ml / €390.00
  Neuromics Antibodies

P2RX3 / P2X3 Control Peptide

P2RX3 / P2X3 Liquid
0.1 mg / €150.00
  Neuromics Antibodies

P2RX3 / P2X3 (C-term) antibody

DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange Rabbit Serum Hu, Mky, Rt C, ICC/IF, WB
50 µl / €190.00
  Neuromics Antibodies

P2RX3 / P2X3 (C-term) antibody

DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange Rabbit Serum Hu, Mky, Rt C, ICC/IF, WB
0.15 ml / €350.00
  Neuromics Antibodies

P2RX3 / P2X3 (C-term) antibody

P2RX3 / P2X3 Rabbit Aff - Purified Hu, Prim, Rt C, ICC/IF, WB
0.1 ml / €350.00
  Neuromics Antibodies

P2RX3 / P2X3 antibody

Immunofluorescence: P2X3 Antibody [NB100-1654] - Double immunofluorescence staining in cultured human bladder urothelial cells (BUCs). BUCs show cytokeratin (red areas) and P2X3 (green areas) expression Rabbit IgG Serum Hu, Mky, Rt F, ICC/IF, P, WB
50 µl / €310.00
  Novus Biologicals Inc.

P2RX3 / P2X3 antibody

P2RX3 / P2X3 Rabbit IgG Hu, Ms, Rt P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

P2RX3 / P2X3

P2RX3 / P2X3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

P2RX3 / P2X3

P2RX3 / P2X3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

P2RX3 / P2X3

P2RX3 / P2X3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

P2RX3 overexpression lysate

P2RX3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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