P2RX4 / P2X4 antibody

Principal name

P2RX4 / P2X4 antibody

Alternative names for P2RX4 / P2X4 antibody

P2X purinoceptor 4, ATP receptor, Purinergic receptor

SwissProt ID

P51577 (Rat), Q5E9U1 (Bovin), Q99571 (Human), Q9JJX6 (Mouse)

Gene ID

5025 (P2RX4), 29659 (P2rx4)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Por (Porcine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of P2RX4 / P2X4 antibody

The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP. The structure and function of the P2X receptors, which were mainly investigated using in vitro models, indicate their involvement in syptic communication, cell death, and differentiation. Seven mammalian P2X receptor subtypes (P2X1â??P2X7) have been identified and cloned.1,2,3 All P2X receptor subtypes share the same structure of intracellular N and C-termini, two membrane-spanning domains and a large extracellular loop. All P2X subunits can assemble to form homomeric or heteromeric functiol channels with the exception of P2X6, which only appears to function as part of a heteromeric complex.4-9 The various P2X receptors show distinct expression patterns. P2X1-6 have been found in the central and peripheral nervous system, while the P2X7 receptor is predomintly found in cells of the immune system.4 The P2X2 receptor subunit has a widespread tissue distribution in autonomic neurons, but it is generally found to be co-expressed with one or more subtypes. Overexpression of P2X4 was demonstrated in microglia and in the spil dorsal horn following peripheral nerve injury. It has been suggested that activation of P2X4 along with p38 MAPK is essential for the development of allodynia (pain from a stimulus that doesn't normally elicit pain) following nerve injury. Inhibition of P2X4 expression in spil microglia has been suggested as a novel therapeutic approach for the treatment of allodynia.10

General readings

Yeung D, Kharidia R, Brown SC, G?recki DC. Enhanced expression of the P2X4 receptor in Duchenne muscular dystrophy correlates with macrophage invasion. Neurobiol Dis. 2004 Mar;15(2):212-20. PMID: 15006691

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

P2RX4 / P2X4 (C-term) antibody

TA303372 (0.3µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

P2RX4 / P2X4 antibody

AP31932PU-N P2RX4 antibody staining of Human Kidney lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

P2RX4 / P2X4 antibody

Western blot analysis of rat brain membranes: 1. Anti-P2X4 Receptor antibody , (1:200). 2. Anti-P2X4 Receptor antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

P2RX4 / P2X4 antibody

WB Suggested Anti-P2RX4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

P2RX4 / P2X4 antibody

Western Blot analysis of P2RX4 expression in transfected 293T cell line (H00005025-T01) by P2RX4 MaxPab polyclonal antibody.

Lane 1: P2RX4 transfected lysate(42.68 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), F, WB
50 µl / €370.00
  Abnova Taiwan Corp.

P2RX4 / P2X4 antibody

Western Blot analysis of P2RX4 expression in transfected 293T cell line (H00005025-T01) by P2RX4 MaxPab polyclonal antibody.

Lane 1: P2RX4 transfected lysate(42.68 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

P2RX4 / P2X4 antibody

Western Blot analysis of P2RX4 expression in transfected 293T cell line (H00005025-T01) by P2RX4 MaxPab polyclonal antibody.

Lane 1: P2RX4 transfected lysate(43.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

P2RX4 / P2X4 antibody

Human Muscle; WB Suggested Anti-P2RX4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Muscle; P2RX4 antibody - N-terminal region (ARP35512_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

P2RX4 / P2X4 antibody

P2RX4 / P2X4 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

P2RX4 / P2X4 antibody

NBP1-00139 (0.3ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

P2RX4 / P2X4 antibody

P2RX4 / P2X4 Rabbit Serum Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

P2RX4 / P2X4 antibody

Immunohistochemistry-Paraffin: P2RX4 Antibody [NBP1-92239] - Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

P2RX4 / P2X4

P2RX4 / P2X4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

P2RX4 / P2X4

P2RX4 / P2X4 Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

P2RX4 293T Cell Transient Overexpression Lysate(Denatured)

P2RX4 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

P2RX4 overexpression lysate

P2RX4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

16 Item(s)

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