PAICS / ADE2 antibody

Principal name

PAICS / ADE2 antibody

Alternative names for PAICS / ADE2 antibody

PAIS, AIRC, Multifunctional protein ADE2

SwissProt ID

P0AG18 (Ecoli), P15567 (Schpo), P21264 (Yeast), P22234 (Human), P38024 (Chick), P51583 (Rat), Q10457 (Caeel), Q9DCL9 (Mouse), Q9I7S8 (Drome)

Gene ID

10606 (PAICS), 140946 (Paics)

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Ms (Mouse), Rt (Rat), African clawed frog, Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PAICS / ADE2 antibody

PAICS is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

General readings

Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAICS / ADE2 antibody

  anti-PAICS mouse monoclonal antibody, clone OTI5B6 (formerly 5B6)  
Anti-PAICS mouse monoclonal antibody (TA501469) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS(RC215225). Mouse IgG2b OTI5B6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PAICS / ADE2 antibody

  PAICS mouse monoclonal antibody, clone OTI1B4 (formerly 1B4)  
Anti-PAICS mouse monoclonal antibody (TA501470) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS(RC215225). Mouse IgG2b OTI1B4 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PAICS / ADE2 antibody

  anti-PAICS mouse monoclonal antibody, clone OTI8A1 (formerly 8A1)  
Anti-PAICS mouse monoclonal antibody (TA501471) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS(RC215225). Mouse IgG2b OTI8A1 Purified Hu F, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PAICS / ADE2 antibody

  anti-PAICS mouse monoclonal antibody, clone OTI2C9 (formerly 2C9)  
Anti-PAICS mouse monoclonal antibody (TA501485) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS(RC215225). Mouse IgG1 OTI2C9 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PAICS / ADE2 (N-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma reacted with PAICS Antibody (N-term) Cat.-No AP53152PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of PAICS Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PAICS / ADE2 antibody

  Rabbit Polyclonal Anti-PAICS Antibody  
WB Suggested Anti-PAICS Antibody Titration: 0.2-1 ug/ml; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

PAICS - human gene knockout kit via CRISPR

PAICS - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PAICS - human gene knockout kit via CRISPR

PAICS - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PAICS - human gene knockout kit via CRISPR

PAICS - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PAICS - human gene knockout kit via CRISPR

PAICS - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PAICS / ADE2 (transcript variant 3)

  Recombinant protein of human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 3  
PAICS / ADE2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PAICS / ADE2 (transcript variant 2)

  Recombinant protein of human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 2  
PAICS / ADE2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PAICS / ADE2 (1-425, His-tag)

PAICS / ADE2 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

PAICS / ADE2 (1-425, His-tag)

PAICS / ADE2 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

PAICS overexpression lysate

PAICS overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

PAICS overexpression lysate

PAICS overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PAICS (mGFP-tagged) - Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, PAICS (mGFP-tagged) - Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PAICS (Myc-DDK tagged) - Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PAICS (Myc-DDK tagged) - Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €920.00
  OriGene Technologies, Inc.

Lenti ORF particles, PAICS (Myc-DDK tagged) - Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PAICS (Myc-DDK tagged) - Human phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Paics (GFP-tagged ORF) - Rat phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (Paics), 200 uL, >10^7 TU/mL

Lenti ORF particles, Paics (GFP-tagged ORF) - Rat phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (Paics), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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