PAK2 antibody

Principal name

PAK2 antibody

Alternative names for PAK2 antibody

PAK 2, PAK-2, Gamma-PAK, PAK gamma, PAK65, p21-activated kinase 2, p58, Serine/threonine-protein kinase PAK 2

SwissProt ID

Q13177 (Human), Q29502 (Rabit), Q64303 (Rat), Q8CIN4 (Mouse)

Gene ID

5062 (PAK2), 29432 (Pak2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Bov (Bovine), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of PAK2 antibody

PAK2 is a ubiquitously expressed, 64kDa, serine/threonine protease found at higher levels in skeletal muscle, ovary, thymus and spleen. p21-activated kinases (PAKs) bind activated Cdc42 and Rac via a Cdc42/Rac interactive binding (CRIB) domain. Group 1 PAK kinases (PAK1, 2 and 3) regulate the activity of an adjacent conserved autoinhibitory domain and are associated with cellular processes, including cytoskeleton rearrangement, apoptosis and MAP kinase signalling. Group 2 PAKs (PAK4, 5, and 6) lack the autoinhibitory domain and are not activated by Cdc42/Rac binding.
PAK2 has a cytostatic effect on cells and is activated in response to cellular stresses such hyperosmolarity, serum starvation, contact inhibition and DNA damage from radiation and chemicals. Unlike other PAKs, PAK2 can be activated by proteolytic cleavage to generate a constitutively active fragment, PAK2p34, which induces a cell death response. This induction is thought to be regulated by Rho GTPase-activating protein 10 which inhibits the protein kinase activity of PAK2p34 and causes it to localise to the perinuclear region instead of the nucleus. PAK2 may also play a role in X-linked mental retardation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAK2 (N-term) antibody

Western blot analysis of PAK2 in Jurkat lysate with PAK2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PAK2 (C-term) antibody

Western blot analysis of PAK2 in Jurkat lysate with PAK2 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PAK2 antibody

Western blot analysis of extracts from HepG2 cells, treated with serum (20%, 15mins), using PAK2 (Ab-192) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAK2 antibody

Western blot analysis of extracts from HeLa cells, treated with TSA (400nM, 24hours), using PAK2 (Ab-141) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAK2 antibody

Western blot analysis of extracts from HT-29 cells, using PAK2 (Ab-197) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAK2 antibody

Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and gastric cancer (right) using PAK2 antibody Cat.-No aM063SU-N with DAB staining. Mouse IgG1 3B5 Ascites Hu, Mky ICC/IF, P, WB
0.1 ml / €450.00
  Acris Antibodies GmbH

PAK2 antibody

PAK2 Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

PAK2 (C-term) antibody

Western blot analysis of whole cell lysate from Jurkat human T-cell leukemia cells probed with Rabbit anti Human PAK2 AP05605PU-S at 0.5 (A) and 1(B) µg/ml. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

PAK2 antibody

Skeletal muscle: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PAK2 antibody

Figure 2. Formalin-Fixed Paraffin-Embedded (FFPE) on Skeletal Muscle. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PAK2 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PAK2 antibody

Immunohistochemistry (IHC) analyzes of PAKγ antibody (Cat.-No.: AP21121PU-N) in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PAK2 Control Peptide

PAK2
50 µg / €160.00
  Acris Antibodies GmbH

PAK2 Control Peptide

PAK2
50 µg / €160.00
  Acris Antibodies GmbH

PAK2 pSer197 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PAK2 (Phospho-Ser197) antibody AP55770PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P
0.1 ml / €340.00
  Acris Antibodies GmbH

PAK2 pSer197 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PAK2 (Phospho-Ser197) antibody AP55770PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P
50 µl / €270.00
  Acris Antibodies GmbH

PAK2 antibody

Western Blot analysis of PAK2 expression in transfected 293T cell line (H00005062-T01) by PAK2 MaxPab polyclonal antibody.

Lane 1: PAK2 transfected lysate(57.64 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PAK2 antibody

Western Blot analysis of PAK2 expression in transfected 293T cell line (H00005062-T02) by PAK2 MaxPab polyclonal antibody.

Lane 1: PAK2 transfected lysate(58.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PAK2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between CASP3 and PAK2 HeLa cells were stained with anti-CASP3 rabbit purified polyclonal 1:1200 and anti-PAK2 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG1 1E1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PAK2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the PAK2 polyclonal antibody ( Cat # PAB2299 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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