PAK4 antibody

Principal name

PAK4 antibody

Alternative names for PAK4 antibody

PAK 4, PAK-4, p21-activated kinase 4, KIAA1142, Serine/threonine-protein kinase PAK 4

SwissProt ID

O96013 (Human), Q8BTW9 (Mouse)

Gene ID

10298 (PAK4), 70584 (Pak4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Can (Canine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PAK4 antibody

The p21-activated kises (PAKs) are serine-threonine kises that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neurol development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.

General readings

Liu Y., et al. (2008). Mol Cancer Res. 6(7):1215-24.
Li X., et al. (2005). J Biol Chem. 280(50):41192-200.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAK4 antibody

  PAK4 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PAK4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807297) Mouse IgG1 OTI1C7 Purified Hu P, WB
0.1 ml / €360.00
  OriGene Technologies, Inc.


PAK4 antibody

Figure 2. Formalin-Fixed Paraffin-Embedded (FFPE) on Spleen. Rabbit Purified Hu P, WB
50 µg / €425.00
  OriGene Technologies GmbH

PAK4 (N-term) antibody

(LEFT)Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.  (RIGHT)Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with PAK4 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH

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