PALB2 antibody

Principal name

PALB2 antibody

Alternative names for PALB2 antibody

FANCN, Partner and localizer of BRCA2

SwissProt ID

Q3U0P1 (Mouse), Q86YC2 (Human)

Gene ID

79728 (PALB2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PALB2 antibody

The dominantly inherited two genes, BRCA1 and BRCA2 that contribute approximately 3-5% of breast cancer, account for approximately 85% of families with four or more cases of breast and ovarian cancer (1). Soon after these genes were discovered, it became apparent that specific founder mutations in these genes were present in different ethnic groups (2), at least 5 founder mutations were discovered that account for 75-85% of all BRCA1/2 mutations in specific ethnic group. However, for approximately one half of strongly hereditary breast cancer families, no BRCA1/2 mutation has been identified and other genes are believed to be important. Several known hereditary genes (BRCA1, BRCA2, CHEK2, TP53, ATM, FANCJ/BRIP1) are known to work in concert in DNA repair pathway which raises the possibility of other genes that might be involved in this pathway and are predispose to breast and other types of cancer (3). Recently identified gene Partner and localizer of BRCA2 (PALB2) is associated with breast cancer susceptibility in the Finland and other European countries. Finland population has shown mutations in PALB2 but these mutations are rare cause of breast cancer incidence in that country (4).
PALB2 is identified to play an important role in facilitating the function of BRCA2; nearly 50% of BRCA2 is associated with PALB2 and more than 50% of PALB2 forms a complex with BRCA2. Association of BRCA2 with PALB2 appears to be essential for BRCA2 anchorage to nuclear structures and for its function in homologous recombination and double-strand break repair (5). The PALB2 may also act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effect of proteosome-mediated degradation. Recent studies suggest that PALB2 is another form of FA gene also known ad FANCN, and FANCMN disease resembles FA arising from biallelic BRCA2 mutations in the affected children that are prone to embryonic tumors and early bone marrow failures. These patients exhibit increased chromosomal breakage after interstrand cross-linking agent exposure, exhibit growth retardation and various congenital malformations (6). The mutations in BRCA2 gene in prostate cancer have been associated with increased prostate cancer risk and account for around 2% of young onset of prostate cancer cases. Interactions of PALB2 with BRCA2 and its role in DNA double stranded break repair suggest a role of PALB2 in prostate cancer. Two previously unreported variants of PALB2, K18R and V925L were identified, neither of which is in a known PALB2 functional domain and both of which are unlikely to be pathogenic in prostate cancer (6). PALB2 (1186 aa) is highly conserved protein expressed in at least 2 variant isoforms in human and mouse/rats is localized on the short arm of chromosome 16p12.1 at position 23,521,983-23,560,127bp.

General readings

Dray, E., et al. Nat. Struct. Mol. Biol. 17(10):1255-1259(2010)
Buisson, R., et al. Nat. Struct. Mol. Biol. 17(10):1247-1254(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Adank, M.A., et al. Pediatr Blood Cancer 55(4):742-744(2010)
Guenard, F., et al. Genet Test Mol Biomarkers 14(4):515-526(2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PALB2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PALB2 Rabbit Polyclonal antibody. (TA590449) Dilution: 1:150 Rabbit IgG Purified Hu E, ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PALB2 antibody

Western blot analysis of PALB2 in SK-N-SH cell lysate with PALB2 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PALB2 control peptide

0.1 mg / €250.00
  Acris Antibodies GmbH

PALB2 (1161-1181) antibody

PALB2 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PALB2 Control Peptide

50 µg / €160.00
  Acris Antibodies GmbH

PALB2 (Center) antibody

Western blot analysis of PALB2 Antibody (Center) Cat.-No AP53155PU-N in HepG2 cell line lysates (35ug/lane).This demonstrates the PALB2 antibody detected the PALB2 protein (arrow). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PALB2 antibody

PALB2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

PALB2 (759-774) antibody

The BCN antibody recognizes FANCN, and its decrease in the presence of siRNA. Whole cell extracts (30 μg) from Hela cells with or without siRNA where fractionated in a 6% SDS-PAGE, transferred to nitrocellulose membrane, and probed with the anti- FANCN BCN antibody diluted 1:500 (Panel A) and with anti-vinculin as loading control (Panel B). Peroxidaseconjugated anti-rabbit antibodies followed by ECL were then used. Rabbit IgG Aff - Purified Hu WB
50 µl / €300.00
  Antibody BCN


Catalog No.    

PALB2 overexpression lysate

PALB2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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