PANX1 antibody

Principal name

PANX1 antibody

Alternative names for PANX1 antibody

Pannexin-1, Pannexin 1, MRS1, PX1, UNQ2529

SwissProt ID

P60570 (Rat), Q96RD7 (Human), Q9JIP4 (Mouse)

Gene ID

24145 (PANX1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of PANX1 antibody

Gap junctions are usually found in clusters and eble intercellular communication by allowing the passage of small molecules between cells. They play important roles in different biological processes. These include differentiation, cell cycle synchronization, cellular development, neurol activity and the immune response. Proteins involved in gap junction formation are composed of four transmembrane domains, 2 extracellular loops and one intracellular loop and intracellular N- and C-termini. Several consensus cysteine residues are in the extracellular loop and are essential and necessary for intercellular docking of gap junction hemichannels in the opposing cell membrane. Pannexins (Pannexin 1, Pannexin 2 and Pannexin 3) belong to the superfamily of gap junction proteins. Pannexin 1 (PANX1) is ubiquitously expressed, Pannexin 2 (PANX2) is specifically expressed in the human brain and widespread in rodents and Pannexin 3 (PANX3) is also detected in the brain. The gating properties of Pannexins were studied in Xenopus oocytes and results demonstrate that only PANX1 is able to form homomeric hemichannels, and is also able to form heteromeric hemichannels with PANX2 but not with PANX3. Not surprising, PANX1 gating properties depend whether it forms homomeric or heteromeric hemichannels. A number of different stimuli are known to open these channels and include mechanical stress, extracellular ATP, increases in intracellular Ca2+ and inflammation. Possible roles for Pannexins include paracrine sigling in vascular endothelial cells and taste cell sigling.

General readings

Barbe MT, Monyer H and Bruzzone R. Cell-cell communication beyond connexins: the pannexin channels. Physiology 2006; 21:103-14.
Baranova A, Ivanov D, Petrash N, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 2004; 83:706-16.
Sohl G, Maxeiner S and Willecke K. Expression and functions of neuronal gap junctions. Nat. Rev. Neurosci. 2005; 6:191-200
Bao L, Locovei S and Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett. 2004; 572:65-8.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PANX1 antibody

Human Intestine; PANX1 antibody - middle region (ARP42783_P050) in Human Intestine cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

PANX1 antibody

Western blot analysis of PANX1 in human ovary tissue lysate with PANX1 antibody at 1 µg/mL. Rabbit Purified Hu, Ms, Rt E, WB
0.1 mg / €345.00
  OriGene Technologies, Inc.

PANX1 (N-term) antibody

Western blot analysis of PANX1 in human ovary tissue lysate with PANX1 antibody at 1 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PANX1 antibody

Western blot analysis of mouse (lanes 1 and 5) and rat (lanes 2 and 6) heart lysates and mouse (lanes 3 and 7) and rat (lanes 4 and 8) brain membranes: 1-4. Anti-Pannexin 1 antibody, (1:400). 5-8. Anti-Pannexin 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

PANX1 (N-term) Control Peptide

PANX1
50 µg / €160.00
  Acris Antibodies GmbH

PANX1 antibody

PANX1 Mouse IgG2a 2E3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PANX1 antibody

Western Blot: pannexin 1 Antibody [NBP1-59672] - This Anti-PANX1 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu P, WB
50 µg / €440.00
  Novus Biologicals Inc.

PANX1 antibody

Immunohistochemistry-Paraffin: Pannexin 1 Antibody [NBP1-92241] -  staining of human ovary shows strong cytoplasmic positivity in follicle cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

PANX1 antibody

Western Blot: Pannexin 1 Antibody (EPR5556) [NBP1-95810] (A) fetal brain, (B) SH-SY5Y, (C) Caco-2, and (D) NIH:OVCAR-3 cell lysates using anti-Pannexin 1. Rabbit EPR5556 Purified Hu, Ms, Rt IP, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Western Blot/IP/ChiP Kits

Catalog No. Host Iso. Clone Pres. React. Applications  

PANX1 Western Blot Kit

PANX1 Western Blot Kit Hu
25 Western Blots / kit / €640.00
  AVIVA Systems Biology

PANX1 Western Blot kit

PANX1 Western Blot kit
1 kit / €640.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PANX1

PANX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PANX1

PANX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PANX1

PANX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PANX1

PANX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PANX1 293T Cell Transient Overexpression Lysate(Denatured)

PANX1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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