Pappalysin-1 / PAPPA antibody

Principal name

Pappalysin-1 / PAPPA antibody

Alternative names for Pappalysin-1 / PAPPA antibody

PAPP-A, IGFBP-4ase, Pregnancy-associated plasma protein A, Insulin-like growth factor-dependent IGF-binding protein 4 protease, IGF-dependent IGFBP-4 protease

SwissProt ID

Q13219 (Human), Q8R4K8 (Mouse)

Gene ID

5069 (PAPPA)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of Pappalysin-1 / PAPPA antibody

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

General readings

General / background references:Qin QP et al. Release patterns of pregnancy associated plasma protein A (PAPP-A) in patients with acute coronary syndromes. Scand Cardiovasc J 36:358-61 (2002). PubMed PMID: 12626203
Bayes-Genis A et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 345:1022-9 (2001). PubMed PMID: 11586954
Lawrence JB et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A 96:3149-53 (1999). PubMed PMID: 10077652
Wald NJ et al. First trimester biochemical screening for Down's syndrome. Ann Med 26:23-9 (1994). PubMed PMID: 7513170

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Pappalysin-1 / PAPPA antibody

ELISA: PAPP A Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2b 1G3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2b 10E1 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2b 10E2 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2b 5H9 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 4G11 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 10A5 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 3C8 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 10H9 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 18A10 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG 11E4 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 7A6 Hu E, IP
0.2 mg / €400.00
  Abnova Taiwan Corp.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 3C8 Purified Hu E, E(detection), IP, WB
1 mg / €330.00
  HyTest Ltd.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 4G11 Purified Hu E, E(capture), IP, WB
1 mg / €330.00
  HyTest Ltd.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2b 5H9 Purified Hu E, E(capture), E(detection), IP, WB
1 mg / €330.00
  HyTest Ltd.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 7A6 Purified Hu E, E(detection), IP, WB
1 mg / €330.00
  HyTest Ltd.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2a 10A5 Purified Hu E, IP, WB
1 mg / €330.00
  HyTest Ltd.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2b 10E1 Purified Hu E, E(capture), E(detection), IP, WB
1 mg / €330.00
  HyTest Ltd.

Pappalysin-1 / PAPPA antibody

Pappalysin-1 / PAPPA Mouse IgG2b 10E2 Purified Hu E, E(capture), E(detection), IP, WB
1 mg / €330.00
  HyTest Ltd.

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