PAPSS1 antibody

Principal name

PAPSS1 antibody

Alternative names for PAPSS1 antibody

ATPSK1, PAPSS, PAPSS 1, Sulfurylase kinase 1, SK1, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

SwissProt ID

O43252 (Human), O54820 (Cavpo), Q60967 (Mouse)

Gene ID

9061 (PAPSS1), 23971 (Papss1)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of PAPSS1 antibody

Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98% identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.

General readings

Girard J.-P., et al. (1998) FASEB J. 12:603-612Venkatachalam K.V., et al. (1999) J. Biol. Chem. 274:2601-2604

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAPSS1 (C-term) antibody

Western blot analysis of anti-PAPSS1 Antibody (C-term) (Cat.#AP12297PU-N) in A2058 cell line lysates (35ug/lane). PAPSS1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PAPSS1 antibody

PAPSS1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PAPSS1 antibody

Western blot analysis of PAPSS1 over-expressed 293 cell line, cotransfected with PAPSS1 Validated Chimera RNAi ( Cat # H00009061-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with PAPSS1 monoclonal antibody (M05), clone 1F4 (Cat # H00009061-M05 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. Mouse IgG2a 1F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PAPSS1 antibody

Western blot analysis of PAPSS1 polyclonal antibody ( Cat # PAB2534 ) in HepG2 cell line lysate ( 35 µg/lane ) . PAPSS1 ( arrow ) was detected using the purified polyclonal antibody ( 1 : 45 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

PAPSS1 - human gene knockout kit via CRISPR

PAPSS1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PAPSS1 - human gene knockout kit via CRISPR

PAPSS1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PAPSS1 - human gene knockout kit via CRISPR

PAPSS1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PAPSS1 - human gene knockout kit via CRISPR

PAPSS1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Papss1 - mouse gene knockout kit via CRISPR

Papss1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Papss1 - mouse gene knockout kit via CRISPR

Papss1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Papss1 - mouse gene knockout kit via CRISPR

Papss1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Papss1 - mouse gene knockout kit via CRISPR

Papss1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PAPSS1

  Recombinant protein of human 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)  
PAPSS1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PAPSS1 (24-624, His-tag)

PAPSS1 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €940.00
  Acris Antibodies GmbH

PAPSS1 (24-624, His-tag)

PAPSS1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

PAPSS1

PAPSS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PAPSS1

PAPSS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PAPSS1

PAPSS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PAPSS1

PAPSS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PAPSS1 (mGFP-tagged) - Human 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), 200 uL, >10^7 TU/mL

Lenti ORF particles, PAPSS1 (mGFP-tagged) - Human 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), 200 uL, >10^7 TU/mL  
200 µl / €1,280.00
  OriGene Technologies, Inc.

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