PAR4 / F2RL3 antibody

Principal name

PAR4 / F2RL3 antibody

Alternative names for PAR4 / F2RL3 antibody

Proteinase-activated receptor 4, PAR-4, Thrombin receptor-like 3, Coagulation factor II receptor-like 3

SwissProt ID

O88634 (Mouse), Q920E0 (Rat), Q96RI0 (Human)

Gene ID

9002 (F2RL3)

Available reactivities

Bt (Bat), Bov (Bovine), Eq (Equine), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Can (Canine), Bear, Rt (Rat)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of PAR4 / F2RL3 antibody

Protease-activated receptor 4 (PAR-4) belongs to a family of four G protein-coupled receptors (PAR-1 - 4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their me. In this novel modality of activation, a specific protease cleaves the PAR receptor within a defined sequence in its extracellular N-termil domain. This results in the creation of a new N-termil tethered ligand, which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several sigl transduction pathways. Different PARs are activated by different proteases. Hence, PAR-4 is activated by both thrombin and trypsin whereas PAR-1 and PAR-3 are activated only by thrombin and PAR-2 is activated only by trypsin. PAR-4 can be also cleaved and activated by other proteases such as cathepsin G. The intracellular sigling mechanisms mediated by PAR-4 activation are not completely elucidated but they involve calcium mobilization downstream of phospholipase Cβ through the Gαq pathway. Tissue distribution of PAR-4 is very broad with the highest expression levels found in lung, testis, pancreas and small intestine. In addition, PAR-4 expression was observed in platelets, megakaryocytes and leukocytes. Studies with platelets derived form PAR-4 knockout mice have established an essential role for PAR-4 in thrombin-induced platelet activation. PAR-4 is likely involved in other physiological functions such as regulation of gastrointestil motility and regulation of vascular endothelial cell function.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PAR4 / F2RL3 (N-term) antibody

Anti-F2RL3 / PAR4 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Elephant, Hu, Mky, Ms, Por, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 antibody

Western blot analysis of rat lung (lanes 1 and 3) and testis (lanes 2 and 4) lysates: 1, 2. Anti-Protease-Activated Receptor-4 (extracellular) antibody, (1:200). 3, 4. Anti-Protease-Activated Receptor-4 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 antibody

Western blot analysis of extracts from 3T3 cells, treated with etoposide (etoposide, 1hour), using PAR4 (Cleaved-Gly48) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 antibody

Western blot analysis of extracts from HeLa cells, Jurkat cells and HepG2 cells, using PAR4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 antibody

Host: Rabbit; Target Name: F2RL3; Sample Tissue: THP-1 Whole Cell lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 (2nd cytopl. dom.) antibody

Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Eq, Hu, Mky, Ms, Por P
50 µg / €379.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 (2nd extracell. dom.) antibody

Anti-F2RL3 / PAR4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Hu, Ms P
50 µg / €379.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 (C-term) antibody

Anti-F2RL3 / PAR4 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

PAR4 / F2RL3 Control Peptide

PAR4 / F2RL3 Purified
50 µg / €220.00
  Acris Antibodies GmbH

PAR4 / F2RL3 antibody

PAR4 / F2RL3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PAR4 / F2RL3 antibody

Detection limit for recombinant GST tagged F2RL3 is approximately 0.03ng/ml as a capture antibody. Mouse IgG1 5F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PAR4 / F2RL3 antibody

PAR4 / F2RL3 Chicken Liquid Hu E, F
0.2 mg / €460.00
  AgriSera AB

PAR4 / F2RL3 antibody

Immunofluorescence analysis of LOVO cells, using PAR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

PAR4 / F2RL3 antibody

Immunofluorescence analysis of LOVO cells, using PAR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

PAR4 / F2RL3 (cleaved) antibody

Western blot analysis of extracts from NIH-3T3 cells, treated with etoposide 25uM 1h, using PAR4 (Cleaved-Gly48) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

PAR4 / F2RL3 (cleaved) antibody

Western blot analysis of extracts from NIH-3T3 cells, treated with etoposide 25uM 1h, using PAR4 (Cleaved-Gly48) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

PAR4 / F2RL3 antibody

Western blot analysis of PAR4 expression in HeLa (A); THP1 (B) whole cell lysates. Rabbit Aff - Purified Hu ICC/IF, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PAR4 / F2RL3 antibody

Western blot analysis of PAR4 expression in HeLa (A); THP1 (B) whole cell lysates. Rabbit Aff - Purified Hu ICC/IF, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PAR4 / F2RL3 antibody

Western blot analysis of PAR4 expression in HeLa (A); THP1 (B) whole cell lysates. Rabbit Aff - Purified Hu ICC/IF, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PAR4 / F2RL3 antibody

Immunohistochemistry-Paraffin: PAR4 Antibody [NBP1-87338] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic and nuclear positivity in neuronal cells and glial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

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