Parafibromin antibody

Principal name

Parafibromin antibody

Alternative names for Parafibromin antibody

CDC73, C1orf28, HRPT2, Cell division cycle protein 73 homolog, Hyperparathyroidism 2 protein

SwissProt ID

Q06697 (Yeast), Q4V8C8 (Rat), Q5ZLM0 (Chick), Q6P1J9 (Human), Q8JZM7 (Mouse)

Gene ID

79577 (CDC73)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Dros (Drosophila)

Available hosts

Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), ChIP assay (ChIP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Parafibromin antibody

Cdc73 (UniProtKB/Swiss-Prot entry Q6P1J9) s a tumor suppressor probably involved in transcriptiol and post-transcriptiol control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with R polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with R polymerase II and coordites the setting of histone marks associated with active transcription. In addition to coorditing events during transcription (initiation, promoter clearance, and elongation), hPAF also coordites events in R quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.

General readings

1. Yart, A. et. al. The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
Mol Cell Biol. 2005 Jun;25(12):5052-60.
2. Woodward, GE et. al. Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene. 2005 Feb 10;24(7):1272-6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Parafibromin antibody

WB was performed using nuclear extracts from HeLa cells (HeLa NE, 20 ug) and the antibody against dCdc73 diluted 1:1,000 in TBS-Tween conatining 5% skimmed milk. A molecular weight marker (in kDa) is shown on the left; the location of the protein of interest is indicated on the right. Rabbit IgG Purified Dros, Hu
0.1 ml / €325.00
  OriGene Technologies, Inc.

Parafibromin antibody

WB was performed on whole cell extracts (WCE) from drosophila larva and drosophila adults (Figure 1A) or on nuclear extracts from HeLa cells (HeLa NE, 20 ug) (Figure 1B) using the antibody against dCdc73 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. A molecular weight marker (in kDa) is shown on the left; the location of the protein of interest is indicated on the right. Rabbit IgG Purified Dros, Hu
50 µg / €325.00
  OriGene Technologies, Inc.

Parafibromin antibody

Western blot was performed using whole cell extracts ( WCE ) from drosophila larva ( Lane 1 ) and drosophila adults ( Lane 2 ) and the CDC73 polyclonal antibody ( Cat # PAB14104 ) at dilution 1 : 1,000 in TBS-Tween + 5% skimmed milk. Rabbit Hu ChIP, WB
50 µg / €470.00
  Abnova Taiwan Corp.

Parafibromin antibody

WB and  IP: Parafibromin Antibody [NB200-184] - Detection of Human Parafibromin on HeLa whole cell lysate using NB200-184. In B, Parafibromin was immunoprecipitated by using NB200-184 at 3 mcg/10mg with or without blocking peptide. Rabbit Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Parafibromin antibody

WB and IP: Parafibromin Antibody [NB200-185] - Detection of Human Parafibromin on HeLa whole cell lysate using NB200-185. In B, Parafibromin was immunoprecipitated by using NB200-185 or control rabbit IgG. Rabbit Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Parafibromin antibody

Western Blot: HRPT2 Antibody [NBP1-32972] - Western blot analysis of HRPT2 on Molt-4 lysates using NBP1-32972. Rabbit IgG Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Parafibromin

Parafibromin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Parafibromin

Parafibromin Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CDC73 overexpression lysate

CDC73 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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