Parathyroid hormone / PTH antibody

Principal name

Parathyroid hormone / PTH antibody

Alternative names for Parathyroid hormone / PTH antibody

Parathormone, Parathyrin

SwissProt ID

P01268 (Bovin), P01269 (Pig), P01270 (Human), P04089 (Rat), P15743 (Chick), P52212 (Canfa), Q27IM2 (Horse), Q9GL67 (Felca)

Gene ID

5741 (PTH)

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Mky (Monkey), Por (Porcine), Ms (Mouse)

Available hosts

Mouse, Rabbit, Rat, Goat, Sheep

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Radioimmunoassay (R), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), ELISA (capture) (E(capture))

Background of Parathyroid hormone / PTH antibody

The rate of parathormone secretion is directly responsive to the level of calcium in the serum, and indeed the cytoplasm, of parathyroid cells, as has been shown by studies both in vivo and in vitro (Brown et al, 1982). Recent in vitro studies of osteoclast turnover suggest that both PTH and PTHrelated protein exert both pro- and anti-apoptotic effects in mesenchymal cells (Chen et al, 2002).
Surgical pathologists are familiar with the ability of parathyroid proliferations to assume a variety of histological guises, posing difficulty to categorize any given lesion as hyperplastic, adenomatous or carcinomatous in nature (Wick et al, 1997). This is usually resolved with macroscopic appearance of the remaining parathyroid glands as assessed by the surgeon. The role of the surgical pathologist is to identify the lesion as parathyroid in nature and to assess whether it is normocellular or hypercellular. Although easily accomplished in the majority of instances, rare examples of parathyroid hyperplasia/adenoma showing a follicular/trabecular arrangement may cause concern over the alternative diagnosis of a thyroid adenoma. This becomes more pertinent when the parathyroid lesion abuts into the thyroid gland or lies within the thyroid capsule. Immunodection for thyroglobulin and parathyroid hormone (PTH) is especially useful to resolve the problem (Permanetter et al, 1983). Nevertheless, caution should be exercised since parathyroid cells often discharge their hormonal product almost as soon as it is packaged in the cytoplasm, resulting in false-negative PTH immunostaining, although the cells are biologically synthetic (Wick et al, 1997).
PTH antibody is also useful to distinguish parathyroid hyperplasia/neoplasms from thyroid and metastatic neoplasms (Wick et al, 1997); although the pathologist is typically aware of the preoperative hypercalcemic status. Occasionally when the surgeon does not supply this information, PTH immunohistochemisty is essential. Even more problematic, are situations in which clear cell parathyroid carcinomas are nonsecretory, without an abnormality in mineral metabolism (Aldinger et al, 1982). In such situations metastatic renal cell carcinoma or metastatic clear cell carcinoma of the lung is evident, warranting PTH immunohistochemistry to arrive at the correct diagnosis (Wick et al, 1997). The other instance in which PTH antibodies are useful, is in the consideration of parathyroid carcinomas located primarily in the anterior mediastinum (intrathymically). In this situation distinction from primary thymic metastatic carcinomas, non-Hodgkin’s lymphoma and germ cell tumors is necessary (Murphy et al, 1986).
The diagnosis of the majority of parathyroid proliferation may be accomplished with an adequate history, biochemistry profile and histomorphological assessment. However, rare instances in which the tumors have an abnormal location, clear cell morphology or a non-secretory may result in erroneous diagnoses, warranting PTH immunohistochemistry.

General readings

Magerlein M, Hock D, Adermann K, Muller-Beckmann B, Neidlein R, Forssmann WG, Stein K. A new immunoenzymometric assay for bioactive Nterminal human parathyroid hormone fragments and its application in pharmacokinetic studies in dogs. Arzneimittelforschung 1998;48:199-204.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Parathyroid hormone / PTH antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-PTH rabbit polyclonal antibody. (TA590804) Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Parathyroid hormone / PTH antibody

Human parathyroid stained with anti-PTH antibody Rabbit IgG SP151 Purified Bov, Can, Hu, Mky, Por P
0.5 ml / €510.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH antibody

Human parathyroid stained with anti-PTH antibody Rabbit IgG SP151 Purified Bov, Can, Hu, Mky, Por P
1 ml / €730.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH antibody

Human parathyroid stained with anti-PTH antibody Rabbit IgG SP151 Purified Bov, Can, Hu, Mky, Por P
0.1 ml / €290.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH antibody

AP15712PU Parathyroid Hormone
antibody staining of Human Parathyroid Gland. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH antibody

AP15712PU Parathyroid Hormone
antibody staining of Human Parathyroid Gland. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH antibody

AP15712PU Parathyroid Hormone
antibody staining of Human Parathyroid Gland. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH antibody

Western blot analysis of extracts from A549 cells, using Parathyroid Hormone antibody (#TA313354).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Parathyroid hormone / PTH antibody

Western blot analysis of extracts of various cell lines, using PTH antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

Parathyroid hormone / PTH antibody

Western blot analysis on A549 cell lysate using Parathyroid Hormone Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Parathyroid hormone / PTH antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTH (RC219848, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTH. Mouse IgG2b OTI1B10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Parathyroid hormone / PTH antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PTH mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800944) Mouse IgG2a OTI1C6 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Parathyroid hormone / PTH antibody

Parathyroid hormone / PTH Mouse IgG2b 3H9 Purified Hu E, P, R
0.2 mg / €390.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH (1-34) antibody

Parathyroid hormone / PTH Rat IgG2b 3B3 Purified Hu C, E, P
0.1 mg / €730.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH (1-34) antibody

Parathyroid hormone / PTH Rat IgG2b 3B3 Purified Hu C, E, P
10 µg / €170.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH (1-37) antibody

Parathyroid hormone / PTH Mouse IgG1 77/78 Purified Hu E, P
0.1 mg / €250.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH (1-37) antibody

Parathyroid hormone / PTH Mouse IgG1 77/78 Purified Hu E, P
10 µg / €110.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH (1-37) antibody

Parathyroid hormone / PTH Mouse IgG1 13/C6315 Purified Hu C, E
0.1 mg / €250.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH (1-37) antibody

Parathyroid hormone / PTH Mouse IgG1 13/C6315 Purified Hu C, E
10 µg / €110.00
  Acris Antibodies GmbH

Parathyroid hormone / PTH (1-38) antibody

Parathyroid hormone / PTH Mouse IgG1 A1/70 Purified Hu C, E, P, R
0.1 mg / €250.00
  Acris Antibodies GmbH

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