PARG antibody

Principal name

PARG antibody

Alternative names for PARG antibody

PARG99, Poly(ADP-ribose) glycohydrolase

SwissProt ID

O02776 (Bovin), O46043 (Drome), O88622 (Mouse), Q86W56 (Human), Q9QYM2 (Rat)

Gene ID

8505 (PARG)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of PARG antibody

Poly(ADP-ribose) glycohydrolase (PARG) is an enzyme possessing both endo- and exoglycosidase activity against poly (ADP-ribose) (PARP), rapidly degrading PARP to release large quantities of free ADP-ribose. PARG is involved in several cellular processes including; apoptosis, DNA repair, cell cycle progression, cell survival and cellular differentiation. During apoptosis, PARG is cleaved by caspase-3 suggesting that PARG activity is regulated during this process. Although encoded by one gene, PARG is present in different cellular localizations as different isoforms: Isoform 1 (111 kDa) is present in the nucleus, Isoform 2 (102 kDA) is in the cytoplasm and Isoform 3 (99 kDa) is mitochondrial. Studies have indicated a critical role for PARG isoform 1 in the quality of sperm chromatin, and subsequent embryonic survival.

General readings

Whatcott, C.J., et al. Exp. Cell Res. 315(20):3477-3485(2009)
Frizzell, K.M., et al. J. Biol. Chem. 284(49):33926-33938(2009)
Erdelyi, K., et al. FASEB J. 23(10):3553-3563(2009)
Ame, J.C., et al. J. Cell. Sci. 122 (PT 12), 1990-2002 (2009)
Uchiumi, F., et al. Genes Cells 13(12):1229-1247(2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PARG antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PARG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808614)(1:150) Mouse IgG2a OTI6F4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PARG (C-term) antibody

Western blot analysis of Parg (arrow) using rabbit polyclonal Parg Antibody (C-term) (Cat.#TA302286).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Parg gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARG antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PARG mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA808508)(1:150) Mouse IgG1 OTI1B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PARG antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PARG (RC208530, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PARG.(1:2000) Mouse IgG2b OTI7F4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PARG antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PARG (RC208530, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PARG.(1:2000) Mouse IgG2b OTI12G3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PARG antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PARG (RC208530, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PARG.(1:2000) Mouse IgG1 OTI9F6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PARG (C-term) antibody

Western blot analysis of PARG Antibody (C-term) Cat.-No AP53163PU-N in NCI-H292 cell line lysates (35ug/lane). This demonstrates the PARG antibody detected the PARG protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PARG antibody

Immunofluorescence of purified MaxPab antibody to PARG on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

PARG antibody

PARG Rabbit Hu C, E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PARG antibody

Immunohistochemistry-Paraffin: PARG Antibody [NBP1-89450] - Immunohistochemical staining of human oral mucosa shows strong cytoplasmic positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PARG

PARG Human
2 µg / €300.00
  Abnova Taiwan Corp.

PARG

PARG Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PARG

PARG Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PARG 293T Cell Transient Overexpression Lysate(Denatured)

PARG 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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