PARK2 / Parkin antibody

Principal name

PARK2 / Parkin antibody

Alternative names for PARK2 / Parkin antibody

PRKN, E3 ubiquitin-protein ligase parkin, PDJ, AR-JP, LPRS2, Parkinson disease 2, Parkinson juvenile disease protein 2

SwissProt ID

O60260 (Human), Q8WW07 (Human), Q9JK66 (Rat), Q9WVS6 (Mouse)

Gene ID

5071 (PARK2), 50873 (Park2), 56816

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), GP (Guinea Pig), Bov (Bovine), Mky (Monkey), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot), Flow Cytometry (F)

Background of PARK2 / Parkin antibody

Park2 functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. Park2 may play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Park2 limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of AR-JP. Park2 may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. Park2 may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Park2 regulates cyclin E during neuronal apoptosis. Park2 may represent a tumor suppressor gene. Park2 promotes the autophagic degradation of dysfunctional depolarized mitochondria.

General readings

Imai Y., et al. (2000) J. Biol. Chem. 275:35661-35664
Shimura H., et al. (2000) Nat. Genet. 25:302-305

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PARK2 / Parkin antibody

  Rabbit polyclonal Parkin Antibody (C-term)  
Park2 Antibody (C-term) (Cat. #TA324839) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Park2 antibody detected the Park2 protein (arrow). Rabbit Ig Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit Anti-Parkin (Ser101) Antibody (Phospho-Specific)  
Western blot of HEK293 cells transfected with Parkin WT (Phospho) and Parkin S101 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~ 52 k parkin protein. The immunolabeling is absent in the parkin S101 mutant. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit Anti-Parkin (Ser378) Antibody (Phospho-Specific)  
Western blot of HEK293 cells transfected with Parkin WT (Phospho) and Parkin S378 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~ 52 k parkin protein.  The immunolabeling is absent in the parkin S378 mutant. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit Polyclonal Parkin Antibody  
The Parkin antibody was tested to pulldown endogenously expressed Parking in HIT-T15 cells (Lane 1, HIT-T15 cells; Lane 2, negative control) and transiently transfected Parkin in Hek cells (Lane 3, Hek cells; Lane 4, negative control). Amount of antibody used: 4ul (=4ug) Lysate of cells used: 1000 ug Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit polyclonal Parkin Antibody (N-term)  
Western blot analysis of lysate from SH-SY5Y cell line, using Park2 Antibody (N-term) (Cat. #TA324838). TA324838 was diluted at 1:1000 at each lane. A goat anti-rabbit (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug. Rabbit Ig Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit polyclonal Parkin antibody  
Western blot analysis of extracts from Jukat cells, using Parkin antibody (#TA326251).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  PARK2 Rabbit Polyclonal Antibody  
Western blot analysis of PC12 cell and brain cell lysate using PARK2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit Polyclonal anti-Park2 antibody  
PARK2 / Parkin Rabbit IgG Purified Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit Polyclonal Anti-Parkin Antibody  
Western blot analysis on HeLa cell lysate using Parkin Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit Polyclonal Anti-PARK2 Antibody  
Western blot analysis of PARK2 in human cerebellum tissue lysate with PARK2 antibody at 1 ug/mL. Rabbit IgG Purified Hu ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

  Rabbit Polyclonal anti-Parkin Antibody  
PARK2 / Parkin Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

Western blot analysis of Parkin antibody (Cat.-No.: AP06276PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

Immunohistochemistry (IHC) analyzes of Parkin antibody (Cat.-No.: AP06437PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

PARK2 / Parkin Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

Immunoprecipitation of PARK2 transfected lysate using anti-PARK2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with PARK2 MaxPab mouse polyclonal antibody (B01) (H00005071-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between PARK2 and DLG1. HeLa cells were stained with anti-PARK2 rabbit purified polyclonal 1:1200 and anti-DLG1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG3 1H4 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

PARK2 immunoreactivity of rat brain extracts and immunobloted with PARK2 polyclonal antibody ( Cat # PAB0714 ) . Lane 1 : Rat brain extracts. Lane 2 : Rat brain extracts preincubated with PARK2. Rabbit GP, Hu, Rt C, Dot, E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

The PARK2 polyclonal antibody ( Cat # PAB4479 ) is used in Western blot to detect PARK2 in mouse brain tissue lysate . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with PARK2 polyclonal antibody ( Cat # PAB4480 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma . Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

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