PARK2 / Parkin antibody

Principal name

PARK2 / Parkin antibody

Alternative names for PARK2 / Parkin antibody

PRKN, E3 ubiquitin-protein ligase parkin, PDJ, AR-JP, LPRS2, Parkinson disease 2, Parkinson juvenile disease protein 2

SwissProt ID

O60260 (Human), Q8WW07 (Human), Q9JK66 (Rat), Q9WVS6 (Mouse)

Gene ID

5071 (PARK2), 50873 (Park2)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), GP (Guinea Pig), Bov (Bovine), Can (Canine), Mky (Monkey), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Dot blot (Dot), ELISA (detection) (E(detection))

Background of PARK2 / Parkin antibody

Function: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP and SEPT5. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin E during neuronal apoptosis. May represent a tumor suppressor gene.; Subcellular location: Cytoplasm. Nucleus. Note: Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies.; Tissue specificity: Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis.

General readings

Sun M, Latourelle JC, Wooten GF, Lew MF, Klein C, Shill HA, Golbe LI, Mark MH, Racette BA, Perlmutter JS, Parsian A, Guttman M, Nicholson G, Xu G, Wilk JB, Saint-Hilaire MH, DeStefano AL, Prakash R, Williamson S, Suchowersky O, Labelle N, Growdon JH, Singer C, Watts RL, Goldwurm S, Pezzoli G, Baker KB, Pramstaller PP, Burn DJ, Chinnery PF, Sherman S, Vieregge P, Litvan I, Gillis T, MacDonald ME, Myers RH, Gusella JF. Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study.Arch Neurol. 2006 Jun;63(6):826-32. PMID: 16769863

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PARK2 / Parkin pSer101 antibody

Figure 1. Western blot of HEK293 cells transfected with Parkin WT (Phospho) and Parkin S101 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~ 52 k parkin protein.  The immunolabeling is absent in the Parkin S101 mutant. Rabbit IgG Aff - Purified Bov, Hu, non-Human Primates WB
0.1 ml / €380.00
  Acris Antibodies GmbH

PARK2 / Parkin pSer378 antibody

Figure 1. Western blot of HEK293 cells transfected with Parkin WT (Phospho) and Parkin S378 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~52 k Parkin protein.  The immunolabeling is absent in the parkin S378 mutant. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €380.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

Park2 Antibody (C-term) (Cat. #TA324839) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Park2 antibody detected the Park2 protein (arrow). Rabbit Ig Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

AP15714PU Parkin antibody staining of Alzheimer's Brain. Rabbit Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

AP15714PU Parkin antibody staining of Alzheimer's Brain. Rabbit Purified Hu, Ms, Rt P
1 ml / €440.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

AP15714PU Parkin antibody staining of Alzheimer's Brain. Rabbit Purified Hu, Ms, Rt P
0.1 ml / €180.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

The Parkin antibody was tested to pulldown endogenously expressed Parking in HIT-T15 cells (Lane 1, HIT-T15 cells; Lane 2, negative control) and transiently transfected Parkin in Hek cells (Lane 3, Hek cells; Lane 4, negative control). Amount of antibody used: 4ul (=4ug) Lysate of cells used: 1000 ug Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

Western blot analysis of lysate from SH-SY5Y cell line, using Park2 Antibody (N-term) (Cat. #TA324838). TA324838 was diluted at 1:1000 at each lane. A goat anti-rabbit (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug. Rabbit Ig Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

Western blot analysis of extracts from Jukat cells, using Parkin antibody (#TA326251).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

Western blot analysis of PC12 cell and brain cell lysate using PARK2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

Western blot analysis on HeLa cell lysate using Parkin Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

Western blot analysis of PARK2 in human cerebellum tissue lysate with PARK2 antibody at 1 ug/mL. Rabbit IgG Purified Hu ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PARK2 / Parkin antibody

Western blot analysis of Parkin antibody (Cat.-No.: AP06276PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

Immunohistochemistry (IHC) analyzes of Parkin antibody (Cat.-No.: AP06437PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PARK2 / Parkin antibody

PARK2 / Parkin Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

Immunoprecipitation of PARK2 transfected lysate using anti-PARK2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with PARK2 MaxPab mouse polyclonal antibody (B01) (H00005071-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between PARK2 and DLG1. HeLa cells were stained with anti-PARK2 rabbit purified polyclonal 1:1200 and anti-DLG1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG3 1H4 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

PARK2 immunoreactivity of rat brain extracts and immunobloted with PARK2 polyclonal antibody ( Cat # PAB0714 ) . Lane 1 : Rat brain extracts. Lane 2 : Rat brain extracts preincubated with PARK2. Rabbit GP, Hu, Rt C, Dot, E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

PARK2 / Parkin antibody

The PARK2 polyclonal antibody ( Cat # PAB4479 ) is used in Western blot to detect PARK2 in mouse brain tissue lysate . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

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